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Menstruation Disturbances clinical trials

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NCT ID: NCT05230316 Active, not recruiting - SLE Clinical Trials

Gynecological Symptoms and Health-related Quality of Life in Egyptian Women With SLE

Start date: January 15, 2022
Phase:
Study type: Observational

The purpose of our study was to Recognize gynecological symptoms and health-related quality of life in Egyptian women with systemic lupus erythematosus and evaluate the impact of duration of remission on QOL in SLE patients.

NCT ID: NCT05224726 Not yet recruiting - Clinical trials for Cesarean Section Complications

Platelet Rich Plasma for Uterine Scar

AA-PRP
Start date: December 2023
Phase: N/A
Study type: Interventional

When vessel wall injury occurs, platelets become activated, releasing more than 30 bioactive proteins, many of which have a fundamental role in hemostasis, inflammation and ultimate wound healing. Platelet-rich plasma (PRP), a modification of fibrin glue made from autologous blood, is being used to deliver growth factors in high concentration to sites requiring wound healing. PRP is obtained from a sample of patients' blood drawn at the time of treatment. As the rate of cesarean deliveries has been rising, long-term adverse sequelae due to uterine scar defects have been increasing. PRP might be a simple preventive treatment that potentially can reduce morbidity following cesarean deliveries.

NCT ID: NCT05197491 Recruiting - Anxiety Clinical Trials

Women's Menstruation During the Covid-19 Pandemic

Start date: April 1, 2022
Phase:
Study type: Observational

The COVID-19 crisis has rapidly become the most significant public health crisis of our times. It has particularly impacted healthcare workers (HCW) due to the over-whelming of healthcare resources, as well as a critical absence of protective equipment and risk to their own health as well as the risk of exposure to their family. All these factors have likely resulted in significant levels of stress, anxiety, and affection of the general health

NCT ID: NCT05107804 Completed - Clinical trials for Menstruation Disturbances

Energy Restriction and Hormones in Premenopausal Women

Start date: March 2001
Phase: N/A
Study type: Interventional

A growing body of epidemiological and biological evidence strongly suggests that physical activity may reduce the risk of breast cancer. Although the mechanism remains unclear, possible links between reduced risk and exercise include favorable alterations in body composition and positive changes in the hormonal milieu. One hormonal biomarker of breast cancer, circulating estrogen, is postulated to be reduced by chronic physical activity, presumably due to disruptive effects of exercise upon menstrual cyclicity, and the potential for loss of body fat with subsequent reductions in the peripheral biosynthesis of circulating estrogens. Although studies have shown that chronic exercise can reduce circulating estrogen, we know little about the magnitude and duration of exposure to an energy deficit required for these changes. Additionally, no studies have addressed the degree to which peripheral production of estrone, versus the ovarian production of estradiol, is altered with exercise that promotes weight/fat loss. A second biomarker of breast cancer, insulin-like growth factor-1 (IGF-1), is presumably increased with exercise but reduced with exercise if energy balance is negative. No prospective studies have addressed whether a moderate aerobic exercise program that results in weight loss will lead to significant changes in IGF-I levels, particularly in individuals of differing initial energy stores. Metabolic energy availability is an important contributing factor in the development of reproductive cancers. However, current methods for assessing energy availability, which include anthropometric measures, calculations of energy balance, evaluation of various serum and urinary biomarkers are prone to measurement error, not sensitive to alterations in energy availability, and are sometimes affected by disease states. The current project includes the introduction of a novel approach to estimating energy status by measuring metabolic hormones in plasma: insulin, IGF-I, insulin-like growth factor binding protein-3 (IGFBP-3) and leptin. This study tested whether a program of moderate aerobic exercise that is combined with a moderate level of dietary restriction would result in significant decreases in two biomarkers of breast cancer, circulating estrogens and IGF-I.

NCT ID: NCT05083065 Completed - COVID-19 Clinical Trials

Evaluation of Menstrual Irregularities and Abnormal Uterine Bleeding After Covid-19 Vaccine

MECOVAC-1
Start date: September 10, 2021
Phase:
Study type: Observational

Covid-19 vaccines offered a good opportunity to counteract the spread of Sars-Cov-2 infection among the general population, reducing significantly both morbidity and mortality. Nevertheless, after the first and second doses of vaccination (regardless of the type of vaccine used) several women required gynaecological visits claiming menstrual Irregularities or abnormal uterine bleeding. Considering this anecdotal evidence, a questionnaire was designed to investigate systematically whether menstrual Irregularities or abnormal uterine bleeding occurred in a significant percentage of women undergoing first and second doses of covid-19 vaccination.

NCT ID: NCT04985591 Completed - Clinical trials for Menstrual Irregularity

The Effect of Liposuction on Menses: a Retrospective Study

Start date: June 14, 2016
Phase: Early Phase 1
Study type: Interventional

The prevalence of obesity nearly tripled from 1975 to 2021, resulting in liposuction, as an effective shaping method, to be performed more frequently. Liposuction is a surgical procedure that uses a specialized instrument to suck fat fragments in the subcutaneous fat layer through a small incision. Analyzing a large sample sizes of patients who had liposuction, we found that some female patients underwent menstrual irregularity after liposuction. In 2004, Carolyn et al. reported several cases in which there was a connection between liposuction and an early onset of menses. Further studies showed that an early onset of menses may be related to the volume of adipose tissue extracted, the amount of anesthesia given, the area of liposuction, and body weight. However, the sample of that study was small, as there were only 17 cases included in the statistical model, and there are few articles in which the impact of liposuction on menses has been studied. To better understand whether menstrual irregularity will occur after liposuction, patients with postmenopausal or preoperative menstrual irregularity were excluded, leaving a sample of 518 female patients to be reviewed. A better understanding of the impact of liposuction on menses may help clinical doctors predict the underlying risk of menstrual irregularity after liposuction and identify individuals at higher risk. The findings may contribute to further understanding of menstrual irregularity.

NCT ID: NCT04985045 Not yet recruiting - Cerebral Palsy Clinical Trials

Menstrual Health and Genital Hygiene Status in Cerebral Palsy

Start date: August 1, 2021
Phase:
Study type: Observational

There is little information about the menstrual health and genital hygiene behaviors of young women with CP. The most important reason for this is that women with CP did not meet the inclusion criteria and were excluded from the study. This may lead to a knowledge gap that limits the design of approaches that can help women and families with CP. Therefore, this study was planned to determine menstrual health and genital hygiene behaviors in women with CP.

NCT ID: NCT04942457 Completed - Fertility Disorders Clinical Trials

Feasibility and Safety of Fasting in Fertility Treatment

KiWuA
Start date: January 10, 2022
Phase: N/A
Study type: Interventional

This exploratory study investigates fasting as a potential supportive therapy in infertility treatment for women suffering from infertility

NCT ID: NCT04940013 Recruiting - Clinical trials for Menstrual Irregularity

Missed Period Pill Study

MPP
Start date: October 25, 2021
Phase: Phase 4
Study type: Interventional

The Missed Period Pill Study is a prospective observational study among people who decide to use misoprostol alone for menstrual regulation.

NCT ID: NCT04938622 Completed - Amenorrhea Clinical Trials

Bioenergetics of Exercise-Induced Menstrual Disturbances

BioE
Start date: May 1, 2001
Phase: N/A
Study type: Interventional

Menstrual disturbances are frequently observed in physically active women and female athletes. Short term prospective studies have shown that diet and exercise interventions can lead to decreases in Luteinizing hormone (LH) pulsatility, however these studies are unable to capture further changes in menstrual status. One longer term prospective study over two menstrual cycles showed that weight loss elicited menstrual disturbances, but there were no quantifiable measurements of energy availability. Thus, the primary purpose of this study was to assess how varying levels of energy deficiency created through a combination of caloric restriction and exercise affect menstrual function in young, premenopausal, sedentary women.