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Menopause, Premature clinical trials

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NCT ID: NCT04071574 Completed - Clinical trials for Polycystic Ovary Syndrome

Comparative Study on the Efficacy of Ovarian Stimulation Protocols on the Success Rate of ICSI in Female Infertility

CS-EOSP-ICSI
Start date: February 1, 2018
Phase: Phase 1/Phase 2
Study type: Interventional

The study will describe the effectiveness of ovarian stimulation in correlation with female infertility causes in a Lebanese population: a comparative study using 5 protocols of ovulation induction (treatment with "A" gonadotropins alone, "B" short GnRH agonist, "C" multiple-dose GnRH antagonist, "D" long GnRH agonist and "E" combined protocol of GnRH antagonist and agonist) and the outcomes of ICSI. This comparative study will help clinicians to select the relevant protocol of ovarian stimulation related to the female infertility disorders.

NCT ID: NCT03924648 Completed - Clinical trials for Premature Ovarian Failure

Endocan Levels in Women With Premature Ovarian Insufficiency

Endocan&POI
Start date: July 1, 2018
Phase:
Study type: Observational [Patient Registry]

Objective: To evaluate serum endocan levels in women with premature ovarian insufficiency (POI) and to compare the results with those of healthy subjects. Methods: This prospective study included 38 women with idiopathic POI and 39 controls. The blood for analysis was obtained at the early follicular phase of the menstrual cycle and serum endocan levels were measured using a commercially available ELISA kit. Follicle-stimulating hormone (FSH), estradiol, and anti-mullerian hormone (AMH) were measured at the same time. The continuous values were evaluated using Student's t-test, and categorical values were evaluated using the Chi-square test. P values < .05 were accepted as significant.

NCT ID: NCT03840824 Completed - Clinical trials for Premature Ovarian Failure

Blood Spot Self-administered Test and Assay

Start date: October 2010
Phase:
Study type: Observational

The current study will compare hormone levels of AMH, FSH and inhibin B in blood specimens collected by venipuncture and fingerstick in a sample of pre-menopausal women ages 18-45 years with normal menstrual cycles.

NCT ID: NCT03692572 Completed - Menopause Clinical Trials

Influence of Early Menopause on Sympathetic Activation and Cardiovascular Function in Older Women

Start date: August 1, 2018
Phase: N/A
Study type: Interventional

Women who enter menopause early are at a greater risk for developing cardiovascular disease later in life as compared to women with normal onset of menopause. This increased risk may be due to a prolonged length of time with decreased hormone levels post-menopause; however, this health risk remains understudied. The current study plan to study why women with early menopause are at higher risk for cardiovascular disease by evaluating their sympathetic nervous system and heart-blood vessel function. In addition, there is lack of promising treatment plans for cardiovascular disease in post-menopausal women. Therefore, the current study will also test the impact of dietary nitrate on post-menopausal women to determine if it might serve as a potential treatment to reduce risk of cardiovascular disease in older women.

NCT ID: NCT03568708 Completed - Clinical trials for Primary Ovarian Insufficiency

Primary Ovarian Insufficiency: Phenotype and Optimal Treatment

Start date: November 1, 2018
Phase: Phase 3
Study type: Interventional

This pilot study will observe the progression of newly diagnosed POI patients physical and psychology outcomes after initiating standard of care HRT treatment in comparison to healthy female control participants' physical and psychology health over 24 months.

NCT ID: NCT03542708 Completed - Clinical trials for Primary Ovarian Insufficiency

Injections of Autologous PRP in Women With Primary Ovarian Insufficiency

PRP4POI
Start date: July 25, 2018
Phase: N/A
Study type: Interventional

Premature ovarian failure is a loss of normal function before age 40, leading to infertility and hypoestrogenism. This study will involve only adult women with a diagnosis of POI. Participants will receive injections of autologous PRP in one randomly selected ovary.

NCT ID: NCT03178695 Completed - Infertility Clinical Trials

Inovium Ovarian Rejuvenation Trials

Start date: June 1, 2017
Phase: Phase 1
Study type: Interventional

The Inovium Ovarian Rejuvenation Treatment is a PRP-based autologous treatment used in combination with a stimulated IVF sequence and Pre-Implantation Genetic Screening to treat infertility in women experiencing menopause, perimenopause, and premature ovarian failure.

NCT ID: NCT02912104 Completed - Infertility Clinical Trials

A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure

POF
Start date: June 20, 2020
Phase: Phase 1
Study type: Interventional

This project will clarify the safety and effectiveness of human amniotic epithelial cells transplantation for the treatment of primary ovarian failure (POF) patients and provide a new therapeutic method for patients with infertility.

NCT ID: NCT02794948 Completed - Clinical trials for Primary Ovarian Insufficiency

Chinese Medicine(Hu Yang Yang Kun Formula) for Primary Ovarian Insufficiency

Start date: April 2016
Phase: Phase 1/Phase 2
Study type: Interventional

The purpose of this research is providing valuable traditional chinese medicine theory and formula in treating Primary Ovarian insufficiency.

NCT ID: NCT02783937 Completed - Clinical trials for Premature Ovarian Failure

Filgrastim for Premature Ovarian Insufficiency

FIL-POI
Start date: November 2016
Phase: Phase 4
Study type: Interventional

Filgrastim is a Granulocyte-Colony Stimulating factor (G-CSF). It is an FDA approved drug. Very small embryonic-like stem cells (VSELs) are found in the ovary. Animal studies showed that these cells are able to regenerate the affected ovary. Studies on mice have shown that Filgrastim result in recovery of oogenesis after chemotherapy-induced gonadal failure (in 2013, 2014, and 2015).