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Filgrastim for Premature Ovarian Insufficiency — FIL-POI  

Premature Ovarian Failure Clinical Trial

Official title:
Filgrastim for Treatment of Premature Ovarian Insufficiency: Randomized Clinical Trial

Clinical Trial Summary

Filgrastim is a Granulocyte-Colony Stimulating factor (G-CSF). It is an FDA approved drug. Very small embryonic-like stem cells (VSELs) are found in the ovary. Animal studies showed that these cells are able to regenerate the affected ovary. Studies on mice have shown that Filgrastim result in recovery of oogenesis after chemotherapy-induced gonadal failure (in 2013, 2014, and 2015).

Clinical Trial Description

Premature ovarian insufficiency (POI) has no curative treatment until now. Filgrastim is an FDA approved Granulocyte-Colony Stimulating factor (G-CSF). Very small embryonic-like stem cells (VSELs) are found in the testis and ovary. VSELs are stem cells that have noticed to survive chemotherapy induced gonadal failure. Data from animal studies showed that stimulation of these stem cells result in generation of the affected gonads. Studies on mice have shown a promising stimulating effect of Filgrastim on recovery of spermatogenesis and oogenesis after chemotherapy-induced gonadal failure (in 2013, 2014, and 2015). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02783937
Study type Interventional
Source South Valley University
Contact
Status Completed
Phase Phase 4
Start date November 2016
Completion date June 2021
View Details
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