Patient-ventilator Asynchrony in Patients With Brain Injury

Mechanical Ventilation Clinical Trial

Official title:

Patient-ventilator Asynchrony in Patients With Brain Injury

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03212482
• Other study ID #: KY 2017-028-02
• Status: Completed
• Start date: June 15, 2017
• Est. completion date: February 29, 2020

Study information

• Verified date: May 2020
• Source: Capital Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Mechanical ventilation is an important support strategy for critically ill patients. It could improve gas exchange, reduce the work of breathing, and improve patient comfort. However, patient-ventilator asynchrony, which defined as a mismatch between the patient and ventilator may obfuscate these goals. Studies have shown that a high incidence of asynchrony (asynchrony index > 10%) is associated with prolonged mechanical ventilation and ICU length of stay and high mortality. So far, there have been only a few studies on the epidemiology of asynchrony in brain-injured patients. Investigators conduct a prospective observational study among brain-injured patients to determine the prevalence, risk factors and outcomes of patient-ventilator asynchrony. Esophageal pressure monitoring, a surrogate for pleural pressure, combined with airway pressure and flow waveforms is used to detect patient-ventilator asynchrony.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: February 29, 2020
• Est. primary completion date: July 1, 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• 1) ]older than 18 years 2) with brain injury in the ICU 3) mechanical ventilated for at least 72 hours

Exclusion Criteria:

• 1) ICU length of stay less than 24 hours 2) enrolled in another trial

Related Conditions & MeSH terms

• Brain Injuries
• Mechanical Ventilation
• Wounds and Injuries

Locations

Country	Name	City	State
China	Jian-Xin Zhou	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Jian-Xin Zhou

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The incidence of patient-ventilator asynchrony in brain-injured patients	The incidence of different types of patient-ventilator asynchrony in brain-injured patients.	Three days
Secondary	The risk factors of patient-ventilator asynchrony in brain-injured patients	The risk factors of different types of patient-ventilator asynchrony in brain-injured patients	Three days