Clinical Trials Logo

Mechanical Thrombectomy clinical trials

View clinical trials related to Mechanical Thrombectomy.

Filter by:
  • Recruiting  
  • Page 1

NCT ID: NCT06149754 Recruiting - Acute Stroke Clinical Trials

BraiN20® Monitoring in Acute Stroke Undergoing Thrombectomy

PROMISE20
Start date: September 15, 2023
Phase:
Study type: Observational

N20 somatosensory evoked potential (SEP) response shows high predictive accuracy of functional recovery in patients with acute ischemic stroke (AIS) undergoing endovascular thrombectomy (EVT). This capacity is independent and even higher than clinical and advanced imaging variables. This study aims to validate BraiN20®, a portable, non-invasive, automatic device to monitor in real-time the presence and characteristics of N20 in AIS patients. 65 patients with AIS and anterior LVO undergoing EVT within 24 hours from onset will be included in three comprehensive stroke centers of Catalonia, Spain. Eligibility criteria are no significant pre-stroke functional dependence, baseline National of Institute of Health Stroke Scale (NIHSS) score equal or higher than 6 points, occlusion (modified Thrombolysis in Cerebral Infarction, (mTICI) 0-1) of the intracranial internal carotid artery (ICA), middle cerebral artery (MCA)-M1 or M2 suitable for EVT per local protocols, without infarct volume restrictions measured by Alberta Stroke Program Early CT (ASPECT) score or by Perfusion Computed Tomography (PCT)/Diffusion Weighted Imaging-Magnetic Resonance Imaging(DWI-MRI) prior to EVT . The primary objective is to confirm an optimal/good reliability of N20 registration before EVT higher than 75% by two blind expert neurophysiologists, assuming a true proportion equal to 87.5%. Secondary endpoints are the predictive accuracy of N20 response recorded by BraiN20® before and after EVT on functional outcome evaluated by the mRS at 7 and 90 days and analyzed by using Receiving Operating Characteristic curves (ROC). A futility interim analysis is planned after the inclusion of 25% population. The trial is sponsored by Time is Brain S.L. and started in September 2023. Primary endpoint results are expected for the first quarter of 2024. BraiN20® could be a useful medical device to predict salvageable brain and functional recovery of patients along the stroke chain.

NCT ID: NCT05899036 Recruiting - Stroke Clinical Trials

Early Feasibility Study of RapidPulseTM Aspiration System for Patients With Acute Ischemic Stroke

PULSE-C
Start date: March 23, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to assess the initial safety and performance of the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 24 hours since the onset of stroke symptoms, or last known normal. Subject will undergo mechanical thrombectomy (a procedure to remove a clot in the brain which is preventing blood flow), with the RapidPulseTM Aspiration System. Participating in the trial is for 5-7 days or hospital discharge (whichever is earlier).

NCT ID: NCT05561088 Recruiting - Clinical trials for Acute Ischemic Stroke

Efficacy and Safety of Head Acupuncture After Mechanical Thrombectomy for Acute Ischemic Stroke

HEALTH
Start date: April 27, 2023
Phase: N/A
Study type: Interventional

To evaluate the efficacy and safety of head acupuncture combined with endovascular therapy for cerebral infarction compared with endovascular therapy alone

NCT ID: NCT05311605 Recruiting - Stroke Clinical Trials

REperfusion Therapy for Acute Ischemic STrOke Due to Large aRtEry Occlusion

RESTORE
Start date: February 23, 2023
Phase:
Study type: Observational [Patient Registry]

The aim of the study was to establish a clinical and advanced imaging database of acute ischemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion of anterior circulation within 24 hours from stroke onset in China, and to investigate the predictors and potential mechanisms of futile recanalization after mechanical thrombectomy.

NCT ID: NCT05175547 Recruiting - Blood Pressure Clinical Trials

Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke

CLEVER
Start date: November 1, 2021
Phase: Phase 3
Study type: Interventional

The CLEVER Study is a prospective, 2-arm, randomized, single-center pilot study to assess the safety and efficacy of intensive blood pressure control using Clevidipine (on-label use) in AIS patients undergoing standard of care mechanical thrombectomy (MT) within 24-hours of symptoms onset.

NCT ID: NCT04664933 Recruiting - Stroke, Ischemic Clinical Trials

Intra-arterial Neuroprotective Strategy for Ischemic STroke Patients With Endovascular Therapy (INSIST-ET)

Start date: December 1, 2020
Phase: N/A
Study type: Interventional

To explore the safety and feasibility of intra-arterial neuroprotective strategy in acute ischemic stroke patients who received recanalization operation.

NCT ID: NCT03754738 Recruiting - Stroke Clinical Trials

Efficacy and Safety of Balloon Guide Catheter in Mechanical Thrombectomy Patients

ESCAPE
Start date: November 25, 2018
Phase: Phase 2
Study type: Interventional

With mechanical thrombectomy now representing standard of care for treatment of acute ischemic stroke secondary to large vessel occlusion, identifying adjunctive techniques that result in improved outcomes for patients with LVO has become an issue of increasing importance. A number of retrospective studies have demonstrated that flow arrest during the clot retrieval process results in less clot fragmentation, lower rates of distal emboli, higher revascularization rates and improved rates of good neurological outcome.