Male Infertility Clinical Trial
Official title:
Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
Korean Red ginseng (KRG) has long been applied to various diseases as a health-promoting
herbal medicine in Korea. Many clinical studies of ginseng have been performed to elucidate
its therapeutic characteristics. KRG has been shown to be effective in many diseases, such as
cancers, hypertension, Alzheimer's disease, diabetes, acquired immune deficiency syndrome,
and sexual dysfunction. Several studies have indicated effects of ginseng on improving
spermatogenesis in animals. The major mechanisms behind these effects were speculated to be
anti-oxidant and anti-aging effects, as well as modulation of the
hypothalamus-pituitary-testis axis [7 - 10]. However, there have been no controlled human
clinical trials to evaluate the effects of KRG on spermatogenesis in patients with male
infertility.
Only a small proportion of causes of male infertility are currently curable, including male
hypogonadal disorders that can be cured by gonadotropic agents, and obstructive azoospermia
that can be corrected by surgery. In addition, evidence-based medicine has revealed that most
empirical treatments are ineffective. Similarly, the efficacies of carnitine, anti-estrogens,
kallikrein, vitamins C and E, and glutathione have not been confirmed.
Therefore, the investigators investigated the effects of KRG on semen parameters in male
infertility patients. This is the first placebo-controlled trial to evaluate the therapeutic
effects of KRG in male patients.
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