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Esketamine and Perioperative Depressive Symptoms

Depressive Symptoms Clinical Trial

Official title:
Effect of Esketamine on Perioperative Depressive Symptoms in Patients Undergoing Major Surgery

Clinical Trial Summary

Perioperative depressive symptoms (PDS) are common in population undergoing surgery, and this would be sharpened especially for complicated, high-risk major surgery. However, None of treatments could resolve this clinical problem during limited perioperative period. The remarkable effects of ketamine on treatment resistant depression have been verified by several clinical trials and the enantiomer S-ketamine (esketamine) showed similar antidepressant efficacy with better safety in recent studies. The efficacy and safety of esketamine administrated intra-operatively for PDS will be verified in this study. Other secondary outcomes such as anxiety, postoperative pain and psychiatric symptoms will also be investigated.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04425473
Study type Interventional
Source Beijing Tiantan Hospital
Contact Ruquan Han, M.D., Ph D.
Phone 8610-59976660
Email ruquan.han@ccmu.edu.cn
Status Recruiting
Phase Phase 2/Phase 3
Start date February 19, 2021
Completion date December 31, 2023
View Details
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