Using 18F-FPEB PET to Identify mGLUR5 Availability in Affective Disorders

Status Recruiting

Clinical Trial Summary

Evidence suggests that mGLUR5 availability may play a key role in the biology of mood disorders. This study aimed to investigate the changes in metabotropic glutamate receptor 5 (mGLUR5) availability and clinical symptoms in patients with MDD and bipolar disorder(BD) after two months of vortioxetine treatment. The investigators hypothesized that patients with MDD and BP have abnormal mGluR5 availability in certain brain regions, and baseline mGLUR5 availability can predict prognosis the prognosis of MDD and BD. fMRI and NODDI are also used to evaluate the function or neurite condition at baseline and 8 week

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05840861
Study type	Observational
Source	Central South University
Contact	Yan Zhang, MD PhD
Phone	13807315182
Email	yan.zhang@csu.edu.cn
Status	Recruiting
Phase
Start date	November 5, 2020
Completion date	September 5, 2023

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