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Clinical Trial Summary

This study looks at the role of the Nociceptin/Orphanin FQ receptor system in the brain of individuals with current or past major depressive disorder (MDD). It also examines how individuals with a history of depression make certain decisions and which brain regions are involved in such decisions. Information collected through MRI, PET, biospecimens (i.e., blood, saliva) and behavioral tasks will be used to predict depressive symptoms in the future.


Clinical Trial Description

The overarching goals of this research are to investigate: (1) the activity of the Nociceptin/Orphanin FQ receptor system among individuals with current or remitted MDD; (2) neural foundations of approach/avoidance behaviors in current or remitted MDDs; (3) stress-induced inflammation in individuals with remitted MDD; (4) neural markers that predict future disease course. This will be achieved through an innovative method of using functional magnetic resonance imaging (fMRI) during an approach/avoidance decision-making task, in addition to a resting positron emission tomography (PET) scan. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05630963
Study type Observational
Source Mclean Hospital
Contact Claire Anderson, BA
Phone 617-855-4290
Email canderson1@mclean.harvard.edu
Status Recruiting
Phase
Start date December 29, 2021
Completion date February 28, 2027

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