Aβ Dynamics in LLMD

Status Recruiting

Clinical Trial Summary

This study will examine the biological factors that may modulate the relationship between depression and the development of Alzheimer's disease (AD). Since the direction of causation between depression and the biological factors associated with AD is unknown, the only way to understand cause and associated risk is to treat the depressive symptoms and examine the effects on AD biomarkers. The study involves an FDA-approved treatment for major depressive disorder. It will compare the SSRI antidepressant escitalopram with placebo. The hypothesis is that a reduction in depressive symptoms will be associated with a normalization of CSF AD biomarkers as well as peripheral inflammatory markers. This research would contribute to fundamental knowledge about potentially modifiable risks of Alzheimer's disease (AD).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05004987
Study type	Interventional
Source	NYU Langone Health
Contact	Antero Sarreal, MD
Phone	845-398-6532
Email	Antero.sarreal@nki.rfmh.org
Status	Recruiting
Phase	Phase 4
Start date	February 4, 2022
Completion date	June 2026

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