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Sumor as Adjuvant Therapy in Treatment-resistant Major Depression — SUSCA  

Major Depressive Disorder Clinical Trial

Official title:
Use of Sumor in the Antidepressant Therapy of Subjects With Major Depression: a Randomized Placebo-controlled Clinical Trial

Clinical Trial Summary

Sumor is a food supplement that combines the main coenzymes of the S-Adenosyl methionine (SAMe) cycle, namely vitamins B6, B12 and folate, with SAMe and betaine. Sumor also contains vitamin C, a molecule that has shown promise in the treatment of depression in experimental models, and selenium, an antioxidant agent whose blood deficiency has been associated with depressive symptoms in some preliminary studies. There are no studies in the literature on the efficacy of this combination in the adjuvant therapy of depression. The purpose of this study is to compare the effects of Sumor in co-therapy with an SSRI antidepressant versus co-therapy with placebo in patients with treatment-resistant Major Depressive Disorder.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04832178
Study type Interventional
Source Azienda Ospedaliero-Universitaria Careggi
Contact Valdo Ricca, MD
Phone +390557947478
Email valdo.ricca@unifi.it
Status Recruiting
Phase Phase 4
Start date June 1, 2021
Completion date June 1, 2024
View Details
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