Major Depressive Disorder Clinical Trial
Official title:
Acceptability and Feasibility of Transcranial Direct Current Stimulation Therapy as a Community-based Treatment for Major Depression
Verified date | June 2022 |
Source | University of East London |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Depression is a prevalent and debilitating disorder. The most common treatments are antidepressant medications and talking therapies. However, for many individuals, these are not their treatment of choice. Furthermore, even following a full course of treatment with an antidepressant or talking therapy, over one third of patients continue to be unwell. The novel brain stimulation treatment, transcranial direct current stimulation (tDCS), is a potential first-line treatment for major depression. The present research question is whether tDCS can be provided as a home-based treatment for major depression for adults with major depression.
Status | Completed |
Enrollment | 26 |
Est. completion date | November 26, 2021 |
Est. primary completion date | November 26, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - diagnosis of major depressive disorder based on DSM-5 criteria - minimum score of 16 on Hamilton Rating Scale for Depression (HAM-D) Exclusion Criteria: - history of treatment-resistant depression - comorbid psychiatric disorder - significant risk of suicide or self harm - any contraindications to tDCS, including implanted electronic medical devices |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of East London | London |
Lead Sponsor | Collaborator |
---|---|
University of East London | King's College London, Rosetrees Trust, University College, London, University of Oxford |
United Kingdom,
Mutz J, Edgcumbe DR, Brunoni AR, Fu CHY. Efficacy and acceptability of non-invasive brain stimulation for the treatment of adult unipolar and bipolar depression: A systematic review and meta-analysis of randomised sham-controlled trials. Neurosci Biobehav Rev. 2018 Sep;92:291-303. doi: 10.1016/j.neubiorev.2018.05.015. Epub 2018 May 12. — View Citation
Mutz J, Vipulananthan V, Carter B, Hurlemann R, Fu CHY, Young AH. Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis. BMJ. 2019 Mar 27;364:l1079. doi: 10.1136/bmj.l1079. — View Citation
Woodham R, Rimmer RM, Mutz J, Fu CHY. Is tDCS a potential first line treatment for major depression? Int Rev Psychiatry. 2021 May;33(3):250-265. doi: 10.1080/09540261.2021.1879030. Epub 2021 Mar 11. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Clinical response | As measured by a HAM-D reduction of >= 50% | At 6 weeks following course of tDCS treatment |
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