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Lung Neoplasms clinical trials

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NCT ID: NCT04762459 Enrolling by invitation - Clinical trials for Non-small Cell Lung Carcinoma

Efficacy and Safety of Almonertinib Combined With or Without Chemotherapy as an Adjuvant Treatment for Stage II-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection

APEX
Start date: August 1, 2021
Phase: Phase 3
Study type: Interventional

This is a multicenter, randomized, open label, phase III study.

NCT ID: NCT04721106 Enrolling by invitation - Lung Neoplasms Clinical Trials

Korea Post Marketing Surveillance (PMS) Study of Vizimpro

Start date: March 12, 2021
Phase:
Study type: Observational

Vizimpro will be approved for the treatment of EGFR NSLCL 1L in Korea. In accordance with the Standards for Re-examination of New Drug, it is required to conduct a PMS. Post marketing surveillance is required to determine any problems or questions associated with Vizimpro after marketing in Korea, with regard to the following clauses under conditions of general clinical practice. Therefore, through this study, effectiveness and safety of Vizimpro will be observed.

NCT ID: NCT04708639 Enrolling by invitation - Lung Cancer Clinical Trials

Monitoring Alectinib Treatment by Detection of ALK Translocations in Serial Blood Samples From Non-Small Cell Lung Cancer Patients

MonAlec
Start date: June 19, 2019
Phase:
Study type: Observational

Circulating tumor DNA can be used to monitor the treatment effect and identify developing resistance mutations during ALK directed TKI treatment.

NCT ID: NCT04697446 Enrolling by invitation - Neoplasms Clinical Trials

External Control, Observational, Retrospective Study Comparing Pralsetinib to Best Available Therapy in Patients With RET-Fusion Positive NSCLC

Start date: December 1, 2020
Phase:
Study type: Observational

This is an external control, observational, retrospective study designed to compare clinical outcomes for pralsetinib compared with best available therapy for patients with RET-fusion positive advanced NSCLC.

NCT ID: NCT04691063 Enrolling by invitation - Clinical trials for Small-cell Lung Cancer

The Study is Being Conducted to Evaluate the Efficacy and Safety of SHR-1316 in Combination With Chemo-radiotherapy in Patients With LS-SCLC.

Start date: January 22, 2021
Phase: Phase 3
Study type: Interventional

The study is being conducted to evaluate the efficacy and safety of SHR-1316 in combination with chemo-radiotherapy in patients with LS-SCLC.

NCT ID: NCT04678440 Enrolling by invitation - Clinical trials for Lung Cancer, Nonsmall Cell

[18F]F-AraG/Total Body PET Imaging and Healthy Subjects and Lung Cancer Patients

Start date: March 31, 2021
Phase: Early Phase 1
Study type: Interventional

In this pilot study, healthy volunteers and patients with Non-Small Cell Lung Cancer will undergo [18F]F-AraG dynamic imaging on the uEXPLORER total body Positron Emission Tomography/Computerized Tomography scanner to obtain preliminary data regarding pharmacokinetics and early biodistribution images.

NCT ID: NCT04478318 Enrolling by invitation - Lymphoma Clinical Trials

Comparison of Imaging Characteristics of uEXPLORER and Conventional PET/CT in Patients With Lung Cancer, Lymphoma, and Melanoma

Start date: June 1, 2020
Phase: N/A
Study type: Interventional

To determine the minimum scan duration for fluorine-18 positron-emitting radioactive isotope-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scans performed on a total-body PET/CT scanner that results in non-inferior image quality to 18F-FDG PET/CT scans performed on a conventional PET/CT scanner. The subject population will be patients being staged for lung cancer, lymphoma, or melanoma.

NCT ID: NCT04366661 Enrolling by invitation - Lung Cancer Clinical Trials

Iraqi Trial for Lung Cancer Screening

ITLUCAS
Start date: June 1, 2018
Phase: N/A
Study type: Interventional

Lung cancer is a global problem. Worldwide, 1.2 million people die of lung cancer each year. In Iraq, lung cancer is the most common malignancy after breast cancer and the leading cause of cancer-related death. Tobacco smoking plays a major role in lung cancer; it is reported in 85-90% of lung cancer patients yet environmental tobacco smoke, environmental and domestic air pollution, work-related risk factors, radon exposure, and viruses may also have an impact on lung cancer incidence rates. Early detection of the disease before patients develop symptoms considers the best way to improve patient outcomes. IT LUCAS is designed to evaluate the utility of low-dose computed tomography (LDCT) screening in early detection and management of lung cancer in high-risk people.

NCT ID: NCT04305613 Enrolling by invitation - Radiation Toxicity Clinical Trials

Cardiotoxicity in Locally Advanced Lung Cancer Patients Treated With Chemoradiation Therapy

CLARITY
Start date: September 14, 2020
Phase:
Study type: Observational

This observational cohort will evaluate the cardiovascular effects of chemoradiation used to treat locally advanced, non-small cell lung cancer. Patients will be enrolled prior to the start of therapy and followed during and for at least 2 years after therapy with echocardiograms, nuclear stress tests, blood sampling, and quality of life surveys.

NCT ID: NCT04191174 Enrolling by invitation - Lung Cancer Clinical Trials

Ventilation Heterogeneity Prior to Lung Resection

Start date: January 6, 2020
Phase:
Study type: Observational

This is a single centre prospective six-week observational study to understand the prevalence and clinical relevance of abnormal ventilation of the lung (assessed by Technegas ventilation single photon emission computed tomography (V SPECT) and hyperpolarized 129Xe magnetic resonance imaging (MRI)), in the presence or absence of airway inflammation (assessed by sputum cell counts), in lung cancer patients prior to lung resection surgery.