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Lung Neoplasm clinical trials

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NCT ID: NCT03664843 Recruiting - Clinical trials for Non-small Cell Lung Cancer

Circulating Tumor DNA Longitudinal Monitoring in Stage III-IV Lung Cancer Patients

Start date: November 9, 2018
Phase:
Study type: Observational

Conduct a prospective study in multicenter to confirm the value of circulating tumor DNA in longitudinal monitoring of stage III-IV lung cancer patients.

NCT ID: NCT03655015 Recruiting - Lung Neoplasm Clinical Trials

Patient-derived Organoid Model and Circulating Tumor Cells for Treatment Response of Lung Cancer

Start date: October 16, 2018
Phase:
Study type: Observational

Create a living biobank of PDOs from Stage I-III lung cancer patients.

NCT ID: NCT03634826 Recruiting - Lung Cancer Clinical Trials

Monitoring of Circulating Tumor DNA and Its Aberrant Methylation in the Surveillance of Surgical Lung Cancer Patients (MEDAL, MEthylation Based Dynamic Analysis for Lung Cancer).

MEDAL
Start date: August 15, 2018
Phase:
Study type: Observational

Conduct a prospective study to confirm the value of circulating tumor DNA and its aberrant methylation in longitudinal monitoring of surgical lung cancer patients.

NCT ID: NCT03368820 Recruiting - Lung Neoplasm Clinical Trials

Cardiovascular Morbidities and Lung Cancer Treatment: a Prospective Registry

Start date: December 4, 2017
Phase:
Study type: Observational [Patient Registry]

Therapeutic algorithms for lung cancer are mainly based on randomised controlled trials which excluded patients with severe co-morbidities. Smoking, the main risk factor for lung cancer, is associated with cardiovascular events that may impact on the therapeutic decision. The aim of this registry is to determine if and how cardiovascular co-morbidities impact on the physicians' decision for anticancer treatment in lung cancer patients by comparing it to the European Lung Cancer Working Party (ELCWP) guidelines

NCT ID: NCT03301961 Recruiting - Carcinoma Clinical Trials

Multiplex Analysis of Circulating Tumor DNA

Start date: April 11, 2019
Phase:
Study type: Observational

Lung cancer is the leading cause of cancer-related death in China. This study will explore the applications of multiplex analysis of circulating tumor DNA biomarkers for diagnosis and surveillance of lung cancer patients

NCT ID: NCT03070626 Recruiting - Lung Neoplasm Clinical Trials

Preoperative Loading With Carbohydrates in Lung Cancer Surgery

Start date: March 20, 2017
Phase: N/A
Study type: Interventional

Administration of preoperative oral carbohydrates are suggested to reduce insulin resistance due to surgical stress. The aim of this study is to investigate whether preoperative oral carbohydrate loading can contribute to lower incidence of postoperative discomfort and to reduce complications in elective lung cancer patients undergoing video assisted thorascopic surgery (VATS).

NCT ID: NCT02992353 Recruiting - Lung Neoplasm Clinical Trials

Single-port, Two-port Versus Three-port VATS on Non-small Cell Lung Cancer

Start date: July 2016
Phase: N/A
Study type: Interventional

In china, the incidence and death rate of lung cancer is 48.32 per 100 000 person-years and 39.27 per 100 000 person-years, respectively, the highest in malignant tumor. Surgical operation is still main treatment means to resectable NSCLC. VATS pulmonary resection is performed in clinical operation with the aim of decreasing postoperative complications morbidity. The mechanisms may be due to minimize the inflammation reaction to surgical injury. There are some trials regarding two-port VATS versus three-port VATS versus four-port VATS or single-port VATS versus three-port VATS. However, there is no prospective randomised controlled trial regarding Single-port versus two-port versus three-port video assisted thoracoscopic pulmonary resection on NSCLC. So, we hope to demonstrate that single-port and two-port VATS were feasible and safe through the trial, and we hope the results of our study will provide a high level of clinical evidence for choosing the best operative approach in VATS.

NCT ID: NCT02984761 Recruiting - Lung Neoplasm Clinical Trials

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

VALOR
Start date: April 13, 2017
Phase: N/A
Study type: Interventional

Patients with stage I non-small cell lung cancer have been historically treated with surgery whenever they are fit for an operation. However, an alternative treatment known as stereotactic radiotherapy now appears to offer an equally effective alternative. Doctors believe both are good treatments and are therefore conducting this study to determine if one may be possibly better than the other.

NCT ID: NCT02965300 Recruiting - Lung Neoplasm Clinical Trials

The Value of VOCs Analysis in Exhaled Breath for Pulmonary Benign and Malignant Lesion Diagnosis

VOCs
Start date: October 2016
Phase: N/A
Study type: Observational

The purpose of this study is to analysis the volatile organic gases(VOCs) in exhaled breath of pulmonary lesion patients and healthy controls, in order to find the difference of composition and concentration among groups.

NCT ID: NCT02906280 Recruiting - Lung Neoplasm Clinical Trials

RCT Comparing 19Ga vs 22Ga EBUS-TBNA Needles in Carcinoma.

Start date: May 2016
Phase: Phase 3
Study type: Interventional

EBUS-TBNA is often the sole diagnostic test applied in patients with stage IV lung cancer. A limitation of the TBNA needle when using a 22 Gauge needle is the limited ability to procure adequate histological samples. Although a larger 19 Ga needle can procure histological samples as demonstrated by the conventional 19 Ga needle, published data are not existing with respect to molecular diagnostics. A new nitinol-based 19 Ga needle has been developed for EBUS-TBNA. Given the frequent usage of 22 Ga needles for molecular diagnostics and the recent technical advancements in 19 Ga needle technology, we conduct a RCT to compare the performance of both needle types.