CMR Right Ventricular Contractile Reserve Following Lung Resection

Lung Cancer Clinical Trial

Official title: Assessment of Right Ventricular Contractile Reserve Following Lung Resection by Dobutamine Stress Cardiac Magnetic Resonance: a Feasibility Study

Status Recruiting

Clinical Trial Summary

Feasibility study investigating CMR dobutamine stress testing before and after lung resection

Clinical Trial Description

We hypothesise that following lung resection,

1. the subtle decrease in RV function and increase in afterload we have demonstrated at rest is associated with a marked impairment of RV function on exercise, termed impaired RV contractile reserve (RVCreserve),

2. impaired RVCreserve is associated with impaired functional capacity .

In this study we aim to assess the feasibility of dobutamine stress cardiovascular magnetic resonance (CMR) scanning to assess RVCreserve pre- and post-operatively in patients undergoing lung resection.

Additionally, we hypothesise that one lung ventilation (with and without lung resection) is associated with biomarker evidence of RV injury.We will perform peri-operative cardiac biomarkers to differentiate between the contribution of major surgery (gastrectomy, lung resection and oesophagectomy), one lung ventilation (lung resection and oesophagectomy) and lung resection on RV injury. ;

Related Conditions & MeSH terms

• Anesthesia
• Lung Cancer
• Surgery

• NCT number: NCT06465277
• Study type: Observational
• Source: Belfast Health and Social Care Trust
• Contact: Adam Glass
• Phone: +442890976378
• Email: a.glass@qub.ac.uk
• Status: Recruiting
• Start date: July 21, 2023
• Completion date: November 2024