| Eligibility |
Inclusion Criteria:
- At least 65 years old;
- Non-small cell lung cancer with locally advanced, recurrent or metastasis, which
confirmed by histologically or cytologically (except sputum cytology) and evaluated as
IIIB-IV stage, who are unresectable or unable to undergo radical radiotherapy or
refuse radical radiotherapy. (If multiple tumor components are mixed, it should be
classified according to their predominant cell type);
- Participants are required to have one measurable disease per RECIST 1.1;
- Unsuitable or unwilling to receive radical treatment methods (such as radical
chemoradiotherapy and/or surgery) and have not received prior systemic therapy;
- ECOG performance status of 0 to 2; The expected survival is more than 3 months;
- Adequate organ and marrow function defined as follows:
- Hemoglobin (HB) =90 g/L (no blood transfusion within 28 days);
- Absolute neutrophil count (ANC) =1.5×109/L;
- Platelet count (PLT) = 100×109/L;
- Aspartate Transaminase (AST) = 1.5 x upper limit of normal (ULN);
- Alaninetransaminase (ALT) = 1.5 x ULN (ALT and AST = 5 x ULN if liver metastases
are present);
- Alkaline phosphatase (ALP) = 1.5 x ULN;
- Albumin (ALB) = 30g/L;
- Creatinine =1.5 x ULN or Creatinine Clearance (CCr) = 60 ml/min;
- International normalized ratio (INR) = 1.5 x ULN;
- Partial thromboplastin time (APTT) = 1.5 x ULN;
- Prothrombin time (PT) = 1.5 x ULN ;
- Thyrotropic hormone (TSH) = ULN (When TSH value is abnormal, T3 and T4 levels is
normal, which can be enrolled);
- Urine protein < (++), or 24-hour urine protein amount < 1.0 g ;
- Patients must have adequate cardiac function, defined as:
Left ventricular ejection fraction (LVEF) > 50% as determined by cardiac echocardiogram.
-Patients enrolled in this study voluntarily and signed an informed consent with a good
compliance.
Exclusion Criteria:
- Participants who have active infection;
- Patients with known immunodeficiency diseases (e.g. psoriasis, active arthritis,
immune nephropathy, HIV, etc);
- Participants with no measurable disease;
- Patients with cancerous meningitis and spinal cord compression;
- Participants with active central nervous system (CNS) metastases (clinically stable
and maintained for at least 2 weeks after adequate treatment of CNS metastases and do
not require treatment such as glucocorticoids and dehydrating drugs are eligible for
enrollment);
- Previously treated with chemotherapy drugs (except neoadjuvant therapy) / targeted
drugs / immunotherapy;
- Participants who were confirmed severe abnormalities of gastrointestinal function
(e.g. inability to take oral medications, uncontrollable nausea or vomiting, history
of major gastrointestinal resection, untreated recurrent diarrhea, untreated gastric
disease requiring long-term acid-suppressing PPI-like medications, Crohn's disease,
ulcerative colitis);
- Patients with central squamous lung cancer on imaging;
- Patients who had an arterial/venous thrombotic event within 6 months, such as
cerebrovascular accident (temporary ischemic attack is excluded), deep vein thrombosis
and pulmonary embolism;
- Patients whose imaging shows that the tumor has invaded a significant vessel or have a
high risk of fatal hemorrhage due to tumor invasion of a significant vessel during the
follow-up study judged by the investigator; or who have bleeding tendencies (e.g.,
active peptic ulcer) or receiving thrombolytic or anticoagulant therapy such as
warfarin, heparin, or their analogs;
- Patients who had antineoplastic therapy against other malignancies, including
radiotherapy, chemotherapy, immunotherapy and herbal medicine (except previously
eradicated malignancies without recurrent metastases for = 5 years);
- Patients with uncontrollable pleural effusion, pericardial effusion or ascites
requiring repeated drainage (except patients who do not require drainage of effusion
or whose effusion does not increase significantly after 3 days of cessation of
drainage);
- Patients who have used immunosuppressive drugs within 4 weeks prior to the study
treatment, except for topical glucocorticoids by nasal spray, inhalation or other
routes or physiologic doses of systemic glucocorticoids (no more than 10 mg/day of
prednisone or equivalent doses of other glucocorticoids);
- Patients who have known or suspected active autoimmune disease (congenital or
acquired), such as interstitial pneumonia, uveitis, enterocolitis, hepatitis,
pituitary inflammation, vasculitis, nephritis, thyroiditis, etc. (Patients with
vitiligo or asthma that has completely resolved in childhood and does not require any
intervention in adulthood may be enrolled; Patients with type I diabetes with good
insulin control may be enrolled);
- Patients who have known allogeneic organ transplantation (except corneal
transplantation) or allogeneic hematopoietic stem cell transplantation;
- Anticipants who have hypersensitivity to any component of anlotinib and monoclonal
antibodies;
- Anticipants who have active interstitial lung disease requiring treatment;
- Anticipants who have a history of psychotropic substance abuse and are unable to
abstain or have a psychiatric disorder;
- Anticipants who have participated in another anti-tumor clinical trial within four
weeks;
- Anticipants who administered anti-infective vaccines (e.g., influenza virus vaccine,
human papillomavirus vaccine) within 4 weeks prior to study therapy; During the
treatment period, in addition to inactive vaccines, other vaccines are prohibited;
- Anticipants who have undergone major surgery (except for diagnostic purposes) within 4
weeks (28 days) prior to the administration of the study;
- Patients who are not suitable for enrollment in the judgment of the investigator.
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