Lung Cancer Clinical Trial
Official title:
A Prospective Study of Longitudinal Monitoring in Surgical Lung Cancer Patients by Circulating Tumor DNA and Its Methylation
Conduct a prospective study to confirm the value of circulating tumor DNA and its aberrant methylation in longitudinal monitoring of surgical lung cancer patients.
Studies have already demonstrated the feasibility of circulating tumor DNA as a surrogate to
reveal tumor mutation status in lung cancer patients and a few researches have shown the
potential ability of using circulating tumor DNA in surveillance. However, no study focused
on the value of methylation status of circulating tumor DNA in the surveillance and no strict
prospective study has been performed in surgical lung cancer patients.
The investigators plan to analyze the dynamic change of circulating tumor DNA and its
methylation status longitudinally from preoperation to long term follow-up in surgical lung
cancer patients, and compare assessment value between circulating tumor DNA detection with
methylation , traditional imaging examinations and traditional blood tumor markers in the
monitoring process.
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