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A Trial of Durvalumab and Tremelimumab in Combination With SBRT in Patients With Metastatic Cancer — ABIMMUNE  

Lung Cancer Clinical Trial

Official title:
A Phase I/II Study Evaluating the Safety and Clinical Activity of Anti-PDL1 (Durvalumab [MEDI4736]) + Anti CTLA-4 (Tremelimumab) Antibodies Administrated in Combination With Stereotactic Body Radiotherapy (SBRT) in Patients With Metastatic Squamous Cell Carcinoma of Head and Neck, Lung, Oesophageus, Cervix, Vagina,Vulva or Anus

Clinical Trial Summary

The study is an open label, multicentric, Phase I/II trial aiming to evaluate the safety, the clinical activity and abscopal anti-tumor effects of a therapeutic strategy associating Durvalumab in conjunction with SBRT or Durvalumab + Tremelimumab in conjunction with SBRT in patients with metastatic squamous cell carcinoma of head and neck, lung, or esophagus.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03212469
Study type Interventional
Source Gustave Roussy, Cancer Campus, Grand Paris
Contact
Status Active, not recruiting
Phase Phase 1/Phase 2
Start date June 20, 2017
Completion date December 2024
View Details
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