Lattice Radiotherapy for Dose-Escalated Palliation of Bulky Tumors

Status Not yet recruiting

Clinical Trial Summary

The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.

Clinical Trial Description

This will be a single-institution, single-arm Phase II trial with an anticipated total of 37 patients enrolled. Treatment will consist of 5 fractions of lattice radiation therapy delivered every other day. The primary endpoints will include the efficacy of lattice therapy as evaluated by ORR (CR or PR per RECIST criteria) at 60 days (2 months) post-treatment and safety. Toxicity will be evaluated at day 5 (+/- 2 days), day 15 (+/- 5 days), day 30 (+/- 5 days), and day 60 (+/- 7 days) post-completion of lattice therapy. This study will also include a translational analysis of the impact of lattice therapy on systemic immune responses. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06416007
Study type	Interventional
Source	University of Cincinnati
Contact	UCCC Clinical Trials Office
Phone	513-584-7698
Email	cancer@uchealth.com
Status	Not yet recruiting
Phase	Phase 2
Start date	June 1, 2024
Completion date	June 1, 2027

View Details

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