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Clinical Trial Summary

The purpose of this research study is to determine if lattice radiation therapy (LRT) will provide better treatment for bulky (large) tumors than current standard of care radiotherapy.


Clinical Trial Description

This will be a single-institution, single-arm Phase II trial with an anticipated total of 37 patients enrolled. Treatment will consist of 5 fractions of lattice radiation therapy delivered every other day. The primary endpoints will include the efficacy of lattice therapy as evaluated by ORR (CR or PR per RECIST criteria) at 60 days (2 months) post-treatment and safety. Toxicity will be evaluated at day 5 (+/- 2 days), day 15 (+/- 5 days), day 30 (+/- 5 days), and day 60 (+/- 7 days) post-completion of lattice therapy. This study will also include a translational analysis of the impact of lattice therapy on systemic immune responses. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06416007
Study type Interventional
Source University of Cincinnati
Contact UCCC Clinical Trials Office
Phone 513-584-7698
Email cancer@uchealth.com
Status Not yet recruiting
Phase Phase 2
Start date June 1, 2024
Completion date June 1, 2027

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