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NCT ID: NCT05868291 Active, not recruiting - Light Clinical Trials

Daylight-controlled Lighting Adjusted for Geographical Orientation : Effects on Recovery, Energy Consumption and User Satisfaction

DIM Light
Start date: November 21, 2022
Phase:
Study type: Observational

The trial takes place in 4 psychiatric closed wards at Ny Psykiatri Bispebjerg. The objective is to compare, retrospectively, over two consecutive winter periods (2022 and 2023) the effect of the lighting on the duration of stay of the patients. During the first winter, a standard lighting is used, and, during the second winter, the lighting will be modified to favor a greater light intensity in blue wave color light in the morning and a gradual decrease in light intensity in the evening adjusted for geographical orientation of the patients' rooms.

NCT ID: NCT05317559 Completed - Light Clinical Trials

Cardiometabolic Outcomes With Light Exposure During Sleep

Start date: February 2014
Phase: N/A
Study type: Interventional

This study tested the hypothesis that acute exposure to light during nighttime sleep adversely affects cardiometabolic function.

NCT ID: NCT05107947 Suspended - Inflammation Clinical Trials

Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm

LIFE
Start date: October 31, 2022
Phase: N/A
Study type: Interventional

The aim of this project is to evaluate the effect of a dynamic light in order to improve the circadian rhythm, provide a better sleep and well-being, and in the long run an improved recovery. The primary question is whether dynamic artificial light with circadian stimulus can affect the circadian rhythm. The secondary question is whether this also provides better sleep and well-being. The group that is particularly interesting to study is a geriatric population that is more sensitive to circadian rhythm disorders, sleep disorders and confusion in connection with hospitalization and that can be of particular benefit from this intervention.

NCT ID: NCT04921215 Recruiting - Sleep Clinical Trials

Teen Sleep and Light Study

Start date: June 14, 2021
Phase: N/A
Study type: Interventional

Circadian clocks shift later (delay) with the progression of puberty; this shift contributes to late sleep onsets in older adolescents. Early school start times, however, force teenagers to awaken earlier than their spontaneous wake time and the opportunity for sleep shortens. Chronic circadian misalignment and sleep restriction are at their peak during late adolescence, and are associated with various negative outcomes. Morning bright light exposure from light boxes can shift rhythms earlier (phase advance) to facilitate earlier sleep onset, and reduce circadian misalignment and the associated risks. Studies of adults, however, indicate that restricted sleep and exposure to evening light due to late bedtimes make morning bright light less effective in producing advances. Pilot data collected from adolescents mimic this finding, but also suggest that staying awake late in normal household lighting and the subsequent sleep restriction before and during a 3-day morning bright light regimen, can shift the system in the wrong direction (phase delay). The overarching goal of this study is to examine the dose of sleep restriction and evening household light that prevents the desired phase advance to morning bright light in adolescents aged 14-17 years. Study 1 aims to construct a sleep restriction with normal household evening light dose-response curve to determine the point at which morning bright light begins to lose its effectiveness. The investigators hypothesize that the circadian system will advance with sufficient sleep, but with increasing sleep restriction/evening light, circadian rhythms will not shift or will delay despite the phase advancing morning bright light. Study 2 will test whether reducing evening light exposure by wearing sunglasses before bedtime during sleep restriction can facilitate phase advances. The main outcome measures to build the dose-response curve will be phase shifts of the central circadian clock marked by the dim light melatonin onset (DLMO) and total sleep time measured from actigraphy in the laboratory. Secondary outcomes include cognitive performance, sleepiness, and mood.

NCT ID: NCT04753190 Recruiting - Sleep Clinical Trials

Light Timing Study

ALT
Start date: August 22, 2022
Phase: N/A
Study type: Interventional

Chronic circadian misalignment and sleep restriction peak during late adolescence, and are associated with morning daytime sleepiness, poor academic performance, conduct problems, depressed mood, suicidal ideation, substance use, insulin resistance, and obesity. Bright light exposure from light boxes can shift rhythms earlier (phase advance) to facilitate earlier sleep onset and reduce morning circadian misalignment and the associated risks. To phase advance circadian rhythms, the investigators' PRCs showed that the ideal time to begin light exposure was slightly before wake-up time and light should be avoided around bedtime because this is when light produces maximum phase delay shifts. An unexpected finding from these results, however, was a second advancing region in the afternoon (~6 to 9 h after habitual wake-up time) suggesting that afternoon light may have more circadian phase advancing ability than traditionally thought. The overall goal of this mechanistic study is to follow-up on the unexpected PRC findings and test whether individually-timed afternoon light alone and in combination with morning bright light can shift circadian rhythms earlier in older adolescents. Four groups will be compared in a randomized parallel group design: afternoon bright light, morning bright light, morning + afternoon bright light, and a dim room light control. Adolescents will complete a 2-week protocol. After a baseline week with a stable sleep schedule, adolescents will live in the laboratory for 7 days. Sleep/dark and the time of bright light exposure will gradually shift earlier. Bright light (~5000 lux) will be timed individually based on his/her stable baseline sleep schedule. The first 3-h morning bright light exposure will begin 1 h before wake on the first morning. The first 3-h afternoon bright light exposure will begin 5 h after wake. The morning + afternoon exposures will begin at the same times, but each exposure will be 1.5 h so that a total of 3 h of bright light per day will be given to each group except the dim light control group. Phase shifts of the circadian clocks marked by the dim light melatonin onset (DLMO) is the main outcome. Investigators hypothesize that afternoon bright light will work synergistically with morning bright light to produce larger shifts than morning or afternoon bright light alone. These data could challenge the current understanding of how to use bright light to shift circadian rhythms earlier.

NCT ID: NCT04666142 Completed - Sleep Clinical Trials

The Effect of Light on Sleep Quality and Physiological Parameters in Individuals in Intensive Care Unit

Start date: May 2, 2019
Phase: N/A
Study type: Interventional

The research was carried out in randomized controlled experimental type in order to determine the effect of light in ICU on patients' sleep quality and physiological parameters. The cases were assigned to the experimental and control groups according to the simple randomization method. The research universe; Between May 2019 and December 2019, sick individuals who were admitted to the 5 isolation rooms in the Reanimation Intensive Care clinic in the education and research hospital in Istanbul were formed. The research sample is; As a result of the power made for the study to be experimentally designed; a total of 148, with a minimum of 74 for each group. In collecting data; Patient Information Form, Numerical Pain Rating Scale, Richards Campbell Sleep Scale, Glaskow Coma Scale, Richmond Agitation Sedation Scale, Bedside Monitors were used to measure physiological parameters. The data obtained as a result of the research were made using the package program named SPSS (IBM SPSS Statistics 24).

NCT ID: NCT03953716 Recruiting - Clinical trials for Primary Dysmenorrhea

Traditional Chinese Medicine, Western Medicine and Low-level Light Therapy(LLLT) for Primary Dysmenorrhea(PD)

Start date: June 22, 2019
Phase: Phase 4
Study type: Interventional

To observe the clinical efficacy and safety of three methods for the treatment of primary dysmenorrhea. Establish an integrated biomarker index system for the evaluation of the efficacy of traditional Chinese medicine, western medicine and Low-level Light Therapy for the treatment of primary dysmenorrhea, and further explore the mechanism and therapeutic material basis of the three treatment methods for the treatment of primary dysmenorrhea

NCT ID: NCT03464084 Completed - Circadian Rhythm Clinical Trials

Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

Start date: February 17, 2018
Phase: N/A
Study type: Interventional

This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.

NCT ID: NCT01873794 Completed - Breast Cancer Clinical Trials

Treating Cancer-Related Fatigue Through Systematic Light Exposure

Start date: January 2012
Phase: N/A
Study type: Interventional

Cancer related fatigue (CRF) - a persistent sense of exhaustion related to cancer or cancer treatment - can severely interfere with activities of daily living, and has even been reported to be a factor in patient requests for hastened death. CRF can represent a serious clinical problem years after all treatment has ended. There is currently no effective treatment for CRF. The purpose of this study is to investigate whether systematic exposure to light (from a commercially available Litebook) reduces CRF or other symptoms.