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Interaction of Melatonin With MTNR1B Genotype on Glucose Control - Study 2

Circadian Rhythm Clinical Trial

Official title:
Interaction of Melatonin and Light With MTNR1B Genotype on Glucose Control - Study 2

Clinical Trial Summary

This project aims to test the impact of melatonin and MTNR1B variation on regulation glucose regulation in a highly controlled in-laboratory setting and ex vivo in pancreatic islets.

Clinical Trial Description

The investigators' recent GWAS discovery of MTNR1B as a novel type 2 diabetes gene has sparked great interest into the role of melatonin in glycemic control, for which the mechanism is largely unknown. This research will determine the effect of melatonin and MTNR1B on glycemic control under highly-controlled, in-laboratory protocols while manipulating circulating melatonin concentrations (both up and down) and assessing glycemic control by frequently-sampled intravenous glucose tolerance tests, as well as in ex vivo human pancreatic islets. This research will provide mechanistic insights into the metabolic effects of melatonin and the MTNR1B risk variant and may help in evidence-based approaches and personalized recommendations to improve glycemic control in night shift workers and late-night eaters. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03464084
Study type Interventional
Source Brigham and Women's Hospital
Contact
Status Completed
Phase N/A
Start date February 17, 2018
Completion date July 19, 2022
View Details
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