Hypertension Clinical Trial
Official title:
The Sero-prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands
The study project can be divided into two parts: (1) health screening for the community and
(2) clinical diagnosis and treatment for patients at National Referral Hospital (NRH) in
Solomon islands. The health screening includes a questionnaire, stool parasitic screening
and blood laboratory tests. A total of 800 subjects will participate in this study. The
collected samples are venous blood (20 ml/per subject) and stool in order to conduct the
related tests mentioned above.
As for the collection of target patients, KMUH will cooperate with NRH to collect two kinds
of blood samples: the blood samples of confirmed malarial cases and those of cases
suspicious of Flaviviral, Alpha-viral, Rickettsial, and Leptospiral infections. The expected
received cases are 600 each year. The venous blood samples (20 ml/per subject) will be used
to conduct related tests mentioned above. At the same time, the subjects will also have to
fill out a related questionnaire which includes height, weight, waist line, heath behavior
and habit, and past history, etc.
KMUH plan a series of medical services to Solomon Islands with the expectation that the
health and medical standard in Solomon Islands can be improved by medical interaction and
the use of high-tech medical instruments. By collecting data from Solomon Islands, KMUH can
better understand the health needs, the characteristics of diseases, and the basic health
information of Solomon Islanders so that the strategies and the operation goals for further
improvement will be more explicit for KMUH's medical teams.
The medical service and study project can be divided into two parts: (1) health screening
for the community and (2) clinical diagnosis and treatment for patients at NRH. The health
screening includes a questionnaire, stool parasitic screening and blood laboratory tests. In
the questionnaire, height, weight, waist line, health behavior and habit, and past history
are investigated. In the laboratory tests, parasite screening, Malaria rapid check,
Flavivirus including dengue virus and Japanese virus, the seroprevalence of Rickettsia, HIV
test, Diabetes, gout, cardiovascular risk factors, and fungal infection are included. A
total of 800 subjects will participate in this study. The collected samples are venous blood
(20ml/per subject) and stool in order to conduct the related tests mentioned above.
As for the collection of target patients, KMUH will cooperate with NRH in the Solomon
islands to collect two kinds of blood samples: the blood samples of confirmed malarial cases
and those of cases suspicious of Flaviviral, Rickettsial,and Leptospiral infections. The
expected received cases are 600 each year. The blood samples of confirmed malarial cases
will be used for pathogen identification and drug resistance analysis. The blood samples
suspicious of Flaviviral(dengue virus, Japanese encephalitis virus), Alpha-viral(Chikungunya
virus, Ross river virus), Rickettsial, and Leptospiral infections will be used for the
following tests of either one, including ICT (immuno- chromatographic test) rapid test,
ELISA, PCR (polymerase chain reaction) and the isolation and identification of pathogens.
The venous blood samples (20ml/per subject) will be used to conduct related tests mentioned
above. At the same time, the subjects will also have to fill out a related questionnaire
which includes height, weight, waist line, heath behavior and habit, and past history, etc.
For the confirmed malarial cases, the frequency of blood drawing will start from the
diagnosed day, and the 3rd, the 7th , the 14th, the 21st , and the28th days after treatment,
with total six times sampling. The blood samples will be used to identify malaria pathogen
types and conduct drug resistance analysis.
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