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Clinical Trial Summary

This study will be investigating the effect of latent tuberculosis infection (LTBI) treatment on glucose tolerance and low-grade inflammation.

Almost a century ago, researchers proposed that diabetes (DM) was associated with increased risk of Tuberculosis infection (TB). A more recent systematic review concluded that DM increases the relative risk for TB 3.1 times. Reversely, TB may affect the glycaemic control; TB is in many cases a chronic infection characterised by long term low-grade inflammation and weight loss, and persons with TB are known to be at risk of hyperglycaemia and DM at time of diagnosis.

A latent infection with the m.tuberculosis bacteria is "silent" without symptoms. 1,7 billion have LTBI on a global scale. Event though the infected person does not experience symptoms, increased background inflammation has been shown in LTBI patients in previous studies. We also know that an increase in inflammatory markers precedes clinical development of DM, and that sub-clinical inflammation contributes to insulin resistance.

We hypothesise that LTBI contributes to dysregulated glucose metabolism due to increased low-grade inflammation, and that treatment will reduce low-grade inflammation and improve glucose tolerance.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04428294
Study type Interventional
Source Herlev and Gentofte Hospital
Contact Niklas Lorentsson, MD
Phone 31 61 79 79
Email niklas_lorentzon@hotmail.com
Status Not yet recruiting
Phase Phase 4
Start date September 2020
Completion date May 2023

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