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Large Vessel Occlusion clinical trials

View clinical trials related to Large Vessel Occlusion.

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NCT ID: NCT06456437 Recruiting - Clinical trials for Acute Ischemic Stroke

Ischemic Post-conditioning in the Treatment of Acute Ischemic Stroke

Start date: November 1, 2021
Phase:
Study type: Observational [Patient Registry]

Post-ischemic adaptation is a physical brain protective treatment strategy in which an ischemic event in an organ or tissue is treated and blood flow is restored, and an ischemic stimulus is given to local tissues to induce the production of anti-ischemic damage factors and reduce the damage associated with reperfusion therapy . Relevant basic studies have confirmed that post-ischemic adaptation can reduce infarct volume and promote neurological function recovery in animal models of cerebral infarction. Therefore, it may be beneficial to the recovery of neurological function in patients with acute ischemic stroke undergoing mechanical thrombus extraction. Based on the above background, the use of a balloon to repeatedly dilate-contract at the original occlusion site after revascularization to block and restore arterial flow may be an effective cerebroprotective treatment for patients with large-vessel occlusion who undergo thrombolysis. However, can this approach be safely used in patients with acute ischemic stroke treated with thrombolysis? What is the protocol for the length of time patients can tolerate post-ischemic adaptation? The application of this method in the treatment of acute ischemic stroke will be explored in this study.

NCT ID: NCT06301412 Not yet recruiting - Ischemic Stroke Clinical Trials

Combination of Hypothermia and Thrombectomy in Acute Stroke

COTTIS-2
Start date: March 18, 2024
Phase: Phase 3
Study type: Interventional

The goal of this clinical trial is to test the combination of hypothermia and endovascular treatment in acute stroke patients with large vessel occlusion. The main question it aims to answer is: does an additional cooling to 35°C result in a benefit on clinical outcome ? Participants receive immediate cooling using a noninvasive transnasal cooling technique (RhonoChill) and are maintained at 35°C for 6 hours after reopening of the vessel using surface cooling, and then slowly rewarmed. Researchers will compare the intervention group (hypothermia and endovascular treatment and best medical treatment including iv thrombolysis) and control group (only endovascular treatment and best medical treatment including iv thrombolysis) to see if additional hypothermia leads to a better outcome after 3 months without relevant complications.

NCT ID: NCT06260969 Recruiting - Clinical trials for Acute Ischemic Stroke

Endovascular Treatment of Acute Ischemic Stroke With Underlying Intracranial Artery Stenosis

Start date: September 1, 2022
Phase:
Study type: Observational [Patient Registry]

The study is a prospective multicentre registry study. Patients admitted to 10 stroke centres nationwide from September 2022 to September 2025 with acute ischaemic stroke due to large vessel occlusion considering underlying ICAS and treated with emergency endovascular thrombolysis were included for analysis. Patients who met the general inclusion criteria underwent thrombectomy and the necessary remedial treatment.

NCT ID: NCT06200753 Recruiting - Clinical trials for Acute Ischemic Stroke

Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)

TRACK-LVO Late
Start date: January 1, 2018
Phase:
Study type: Observational

The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each participating center beyond 24 hours from last known well, who are treated with either endovascular therapy (EVT) or the best available medical management (BMM).

NCT ID: NCT06138834 Not yet recruiting - Clinical trials for Acute Ischemic Stroke

EFfects of Y-6 SUblingual Tablets foR PaTients With AcUte Ischemic StRokE (FUTURE)

Start date: November 2023
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy. Moreover, we expect to evaluate the safety of using Y-6 sublingual tablet in such study population.

NCT ID: NCT05953623 Not yet recruiting - Clinical trials for Stroke, Acute Ischemic

Intra-arterial Albumin Infusion After Endovascular Therapy for Stroke Patients

Start date: August 1, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is to investigate the safety and feasibility of intra-arterial albumin infusion for patients with acute ischemic stroke after successful thrombectomy and to further explore the optimal dose of albumin through the implementation of a 3 + 3 dose-escalation design.

NCT ID: NCT05899036 Recruiting - Stroke Clinical Trials

Early Feasibility Study of RapidPulseTM Aspiration System for Patients With Acute Ischemic Stroke

PULSE-C
Start date: March 23, 2024
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to assess the initial safety and performance of the RapidPulseTM Aspiration System in patients experiencing acute ischemic stroke within 24 hours since the onset of stroke symptoms, or last known normal. Subject will undergo mechanical thrombectomy (a procedure to remove a clot in the brain which is preventing blood flow), with the RapidPulseTM Aspiration System. Participating in the trial is for 5-7 days or hospital discharge (whichever is earlier).

NCT ID: NCT05885178 Enrolling by invitation - Clinical trials for Stroke, Acute Ischemic

Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-1 (TRACK-LVO-1)

TRACK-LVO-1
Start date: January 1, 2018
Phase:
Study type: Observational

The aim of this study is to establish an academic, real-world, single-center, observational registry of consecutive patients hospitalized with acute ischemic stroke (AIS) due to large vessel occlusions (LVO), treated with either endovascular therapy (EVT) or best medical management (BMM).

NCT ID: NCT05864638 Recruiting - Clinical trials for Acute Ischemic Stroke

A Multicenter Registry of Endovascular Treatment for Acute Ischemic Stroke

Start date: May 10, 2023
Phase:
Study type: Observational [Patient Registry]

A Multicenter Registry of Endovascular Treatment for Acute Ischemic Stroke.

NCT ID: NCT05836766 Recruiting - Clinical trials for Acute Ischemic Stroke

Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion

CRYSTAL
Start date: June 5, 2023
Phase: Phase 2
Study type: Interventional

This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy. Moreover, we expect to evaluate the safety of using Y-6 sublingual tablet in such study population.