Polycystic Ovary Syndrome Clinical Trial
Official title:
Effect of Laparoscopic Sleeve Gastrectomy (LSG) on Live Birth Rate of Offspring in Polycystic Ovarian Syndrome (PCOS) Patients With Severely Obese
This is a experimental study, which subjects are obese PCOS patients requiring LSG surgery. Aim to investigate the effects of LSG surgery in PCOS patients whether increases the live birth rate of the offspring.
The investigators designed a single center small sample exploratory study to clear the
therapeutic effects of laparoscopic sleeve gastrectomy on live birth rate improvements of
overweight/obese PCOS patients. The investigators plan to enroll 18 patients. Inclusion
criteria: 1) Patients who are aged from 18 to 45, not menopause;2) have PCOS which is
diagnosed according to 2003 Rotterdam criteria; 3) have been treated with behavioral and
drugs intervention for 3 months but are ineffective; 4) have steady or steady weight gain
over 5 years, BMI>35kg/m2, or BMI>30kg/m2 with one of the metabolic disorders such as
impaired glucose tolerance, cardiovascular disease, fatty liver, lipid metabolism disorders,
sleep apnea syndrome.
Patients with serious complications (cardiovascular events and recent significant liver,
kidney or lung disease within 3 months); high blood pressure (>160/100mmHg); active
infection; secondary diabetes; pregnancy; alcohol abuse; surgical contraindications are
excluded.
Then the investigators plan to perform laparoscopic sleeve gastrectomy . Before and after the
intervention, the blood samples would be collected to detect blood glucose, insulin, lipid
profile, sex hormones, blood chemistry for liver and kidney function, hsCRP etc., as well as
the anthropometric measurement and image examinations. All patients are followed up every 3
months until the end of the program. All patients receive MRI plain scan of upper and lower
abdomen, oral glucose tolerance test (OGTT) and insulin, C-peptide releasing test again every
6 months after the operation. One year after the operation, patients would be evaluated
whether they are suitable for pregnancy preparation and record the pregnancy mode. After
pregnancy, various indicators would be closely monitored, including maternal vitamin and
trace element levels.The birth of children and the live birth rate would be recorded.
The investigators will compare the data and finally identify the treatment effect of
laparoscopic sleeve gastrectomy on overweight/obese PCOS patients.
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