Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis

Language Clinical Trial

Official title:

Mechanism of Aphasia and Recovery of Language After the Injury of Geschwind's Territory: a Study Based on the Brain Network Analysis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04295980
• Other study ID #: 81901175
• Status: Recruiting
• Start date: January 1, 2020
• Est. completion date: December 31, 2022

Study information

• Verified date: March 2020
• Source: Beijing Tiantan Hospital
• Contact: Yuming Jiao, MD
• Phone: 8615010108242
• Email: shengxiongyuming[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

At present, functional imaging studies have suggested that the Geschwind's territory (the inferior parietal lobe) is an important language area. It is the hub for semantics and phonetic language processing. However, the type and mechanism of aphasia after injury of Geschwind's territory and the subsequent recovery of language are still unclear. In our study based on brain injury model of brain arteriovenous malformation (BAVMs) resection, investigators found that the incidence of aphasia was higher after the injury of Geschwind's territory than after injury of the classical language area, and the type of aphasia was complicated, while the recovery rate of language disorder was high during follow-up. Investigators hypothesized that the type of aphasia may be associated with the type of brain connectivity damaged, and that reorganization of brain connections and brain network promote the recovery of language function. In this study, we aim to investigate the types of aphasia and their corresponding brain network changes after the resection of BAVMs located in the Geschwind's territory. Investigators will evaluate language function and collect multimodality images of the patients before resection of the lesions, as well as 7 days, 3 months and 6 months afterwards. In addition, the anatomical brain connectivity and brain network will also be analyzed. Our research will not only be a meaningful exploration for mechanisms of human language function damage and reorganization, but will also provide an important basis for the protection of brain function in neurosurgery.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 80
• Est. completion date: December 31, 2022
• Est. primary completion date: July 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

1. Signed the informed consent form;

2. The dominant hand is the right hand (evaluated by the Edinburgh hand scale);

3. BAVM located in the left inferior parietal lobe

4. No history of rupture and bleeding and neurosurgical treatment

Exclusion Criteria:

1. There are implants in the body (cardiac pacemaker, artificial femoral head, etc.);

2. The dominant hand is unclear;

3. Illiterate or other patients who can not cooperate well with cognitive function tests;

4. The history of bleeding in BAVM patients within one month;

5. History of neurosurgical treatment.

Related Conditions & MeSH terms

• Aphasia
• Arteriovenous Malformations
• AVM - Cerebral Arteriovenous Malformation
• Intracranial Arteriovenous Malformations
• Language

Intervention

Procedure:
• Surgical removal of the BAVMs
Resection the BAVM nidus by microsurgery.

Locations

Country	Name	City	State
China	Beijing Tiantan Hospital, Capital Medical University	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Beijing Tiantan Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain network of BAVMs in Geschwind's area	compare the brain network of the Geschwind's area BAVMs patients and normal controls	2 years
Primary	Brain network after injury of Geschwind's area	compare the preoperative and postoperative brain network of Geschwind's area BAVMs.	2 years
Primary	Brain network of the brain reorganization after surgery	After surgery, we compare the brain network before and after the reorganization.	3 years