SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS

Knee Osteoarthritis Clinical Trial

Official title:

SUPPLEMENTARY EFFECTS OF RESISTANCE TRAINING IN ADDITION TO JOINT MOBILIZATION IN PERSONS WITH KNEE OSTEOARTHRITIS

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT06444932
• Other study ID #: FUI/CTR/2024/12
• Status: Enrolling by invitation
• Phase: N/A
• Start date: June 10, 2024
• Est. completion date: December 30, 2024

Study information

• Verified date: June 2024
• Source: Foundation University Islamabad
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Joint mobilization and resistance exercise training are effective conservative treatment options for the management of osteoarthritis. However, currently no study has highlighted the supplementary effects of resistance training in addition to joint mobilization in people suffering from knee osteoarthritis. The current study is aimed at bridging the gap in literature and providing evidence regarding the additive impact of resistance training to joint mobilization in knee osteoarthritis.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 44
• Est. completion date: December 30, 2024
• Est. primary completion date: December 10, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 40 Years to 70 Years

Eligibility

Inclusion Criteria:

• Knee OA grade I-III
• Individuals of either gender aged 40-70 years
• Knee OA history of no less than 3 months
• Knee pain no more than 8/10 cm on the visual analogue scale (VAS)
• Radiological evidence of grade III or less on Kellgren classification.

Exclusion Criteria:

• Those with signs of serious pathology such as malignancy, inflammatory disorder or infection.
• History of trauma or fractures in lower extremity
• Signs of lumbar radiculopathy or myelopathy
• History of knee surgery or replacement and/or receiving intra-articular steroid therapy in the preceding two months

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Procedure:
• Joint Mobilization
Patellofemoral and tibiofemoral joint mobilization
• Resistance Exercise Training
Lower limb resistance exercise training

Device:
• Transcutaneous Electric Nerve Stimulation (TENS)
Transcutaneous Electric Nerve Stimulation (TENS)
• Heating Pad
Heating pad for heat therapy

Locations

Country	Name	City	State
Pakistan	Foundation Univeristy Islamabad	Islamabad

Sponsors (1)

Lead Sponsor	Collaborator
Foundation University Islamabad

Country where clinical trial is conducted

Pakistan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Walking related performance fatigability	Walking related performance fatigability will be measured using 6 minute walk test. Greater fatigability indicates poorer outcome.	4 weeks
Primary	Stride Length	Gait analysis will be done to analyze stride length. A greater stride length signifies positive outcome and prognosis.	4 weeks
Primary	Gait velocity	Gait analysis will be done to analyze gaot velocity. A greater gait velocity signifies positive outcome and prognosis.	4 weeks
Primary	Knee Pain	Knee Pain will be measured using visual analogue scale (VAS) from 0-100mm. A higher score on VAS indicated greater pain.	4 weeks
Primary	Knee range of motion	Knee range of motion will be measured using a goniometer. A higher ROM signifies positive outcome.	4 weeks
Primary	Functional Disability	Knee functional disability will be assessed using Knee Osteoarthritis and Outcome Score (KOOS) with a score ranging from 0-100. A lower score on KOOS signifies greater functional disability.	4 weeks
Primary	Isometric Muscle Strength	Isometric Muscle Strength will be quantified using dynamometer. A higher score on dynamometer signifies greater muscle strength and good prognosis.	4 weeks
Primary	Functional capacity	5 repetition sit to stand test will be used to determine knee related functional capacity, which will be quantified in terms of time. A smaller time will denote greater functional capacity.	4 weeks