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NCT06408922 Clinical Trial

Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:
Comparison of the Effects of Single Versus Triple Injections of Platelet-Rich Plasma in Patients With Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT06408922
Other study ID # prpknee2023
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date April 15, 2023
Est. completion date April 15, 2024

Study information
Verified date May 2024
Source Izmir Democracy University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

80 patients diagnosed with knee osteoarthritis were randomized into two groups: patients in Group 1 received a single intraarticular injection of PRP whereas those in group 2 were administered three intraarticular injections of PRP within an interval of 2 weeks between each application. Patients were evaluated before the treatment and at the 6 month after the treatment with a Visual Analog Scale (VAS) and The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index.

Recruitment information / eligibility
Status Completed
Enrollment 80
Est. completion date April 15, 2024
Est. primary completion date April 1, 2024
Accepts healthy volunteers No
Gender All
Age group 35 Years to 80 Years
Eligibility Inclusion Criteria: - ages of 35 and 80 - Kellgren-Lawrence grade of 2, 3, or 4 Exclusion Criteria: - rheumatic diseases, coagulopathies, severe cardiovascular diseases, local infections, malignancies, immunodeficiency, schizophrenia, mental retardation, anticoagulant therapy, a hemoglobin concentration of 11 g/dL and platelets of 150,000/L, a history of severe trauma, or a history of hyaluronic acid or corticosteroid injection within the previous 6 months

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• prp injection
intraarticular prp

Locations
Country Name City State
Turkey Buca Seyfi Demirsoy Training and Research Hospital Izmir

Sponsors (1)
Lead Sponsor Collaborator
Izmir Democracy University

Country where clinical trial is conducted

Turkey, 

Outcome
Type Measure Description Time frame Safety issue
Primary The Western Ontario and MacMaster Universities (WOMAC) Osteoarthritis Index baseline and 6 months
Secondary Visual Analog Scale (VAS) baseline and 6 months
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