The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:

The Relationship of Serum Uric Acid With Severity of Knee Osteoarthritis

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06149078
• Other study ID #: Soh-Med-23-11-10MS
• Status: Not yet recruiting
• Start date: December 10, 2023
• Est. completion date: May 10, 2024

Study information

• Verified date: November 2023
• Source: Sohag University
• Contact: Aya M Saber, resident
• Phone: 01278825940
• Email: ayamohamed[@]med.sohag.edu.eg
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Osteoarthritis (OA) is the most prevalent form of arthritis. Its pathogenesis remains poorly understood. Though historically regarded as a disease of mechanical degeneration, it is now appreciated that inflammation plays an important role in OA pathogenesis (Krasnokutsky et al., 2017). The hallmark of OA is the degradation and loss of articular cartilage, although most tissues of the joint become affected, such as bone, synovium, ligaments, menisci (knee), labrum (hip), periarticular fat, and muscle (Englund, 2023).It is believed that there is a pathological link between hyperuricemia and OA Therefore, we conducted a cross-sectional study to evaluate an association between elevated SUA and radiographic OA of the knee) Bipan Shrestha, 2019 (.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 150
• Est. completion date: May 10, 2024
• Est. primary completion date: May 10, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adult patient (Age>18 years) with a complaint of knee pain.

Exclusion Criteria:

• 1.Any patient with a history of trauma to the knee. 2 Any patient with knee complaints as a part of autoimmune connective tissue disease.

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Diagnostic Test:
• serum uric acid
to detect the relaton ship of serum uric acid with sevwrity of knee osteoarthritis

Locations

Country	Name	City	State
Egypt	Sohag university Hospital	Sohag

Sponsors (1)

Lead Sponsor	Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

References & Publications (3)

Englund M. Osteoarthritis, part of life or a curable disease? A bird's-eye view. J Intern Med. 2023 Jun;293(6):681-693. doi: 10.1111/joim.13634. Epub 2023 Apr 2. — View Citation

Krasnokutsky S, Oshinsky C, Attur M, Ma S, Zhou H, Zheng F, Chen M, Patel J, Samuels J, Pike VC, Regatte R, Bencardino J, Rybak L, Abramson S, Pillinger MH. Serum Urate Levels Predict Joint Space Narrowing in Non-Gout Patients With Medial Knee Osteoarthritis. Arthritis Rheumatol. 2017 Jun;69(6):1213-1220. doi: 10.1002/art.40069. Epub 2017 Apr 28. — View Citation

Park D, Park YM, Ko SH, Hyun KS, Choi YH, Min DU, Han K, Koh HS. Association of general and central obesity, and their changes with risk of knee osteoarthritis: a nationwide population-based cohort study. Sci Rep. 2023 Mar 7;13(1):3796. doi: 10.1038/s41598-023-30727-4. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	percentage of serum uric acid	detect the relationship of serum uric acid with severity of knee osteoarthritis	6 months