Improved Pain Management in Knee Osteoarthritis-related Surgeries

Knee Osteoarthritis Clinical Trial

Official title:

Evaluating the Effectiveness of Continuously Improved Pain Management in Knee Osteoarthritis-related Surgeries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06124170
• Other study ID #: 2023-414
• Status: Completed
• Start date: March 1, 2016
• Est. completion date: March 2, 2023

Study information

• Verified date: November 2023
• Source: Sichuan Provincial People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

Description:

We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 714
• Est. completion date: March 2, 2023
• Est. primary completion date: March 2, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• first knee surgery were 50-80 years old had complete clinical and follow-up data

Exclusion Criteria:

• American Society of Anesthesiologists Physical Status grade=4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration

Related Conditions & MeSH terms

• Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee
• Pain Management
• Total Knee Arthroplasty
• Unicompartmental Knee Arthroplasty

Intervention

Procedure:
• Preoperative pain managment
propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery
• Intraoperative pain managment
Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;
• Postoperative pain managment
The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Locations

Country	Name	City	State
China	Sichuan Provincial People's Hospital	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
Peng Liu

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Self-Rating Anxiety Scale (SAS)	Self-Rating Anxiety Scale (SAS)	24 hours after surgery
Other	Self-Rating Anxiety Scale (SAS)	Self-Rating Anxiety Scale (SAS)	72 hours after surgery
Other	Self-Rating Depression Scale (SDS)	Self-Rating Depression Scale (SDS)	24 hours after surgery
Other	Self-Rating Depression Scale (SDS)	Self-Rating Depression Scale (SDS)	72 hours after surgery
Primary	visual analogue score (VAS)	visual analogue score (VAS)	24 hours after surgery
Primary	visual analogue score (VAS)	visual analogue score (VAS)	72 hours after surgery
Secondary	Quadriceps muscle strength	Quadriceps muscle strength	24 hours after surgery
Secondary	Quadriceps muscle strength	Quadriceps muscle strength	72 hours after surgery
Secondary	Scope of activities to knee joint	Scope of activities to knee joint	24 hours after surgery
Secondary	Scope of activities to knee joint	Scope of activities to knee joint	72 hours after surgery