| Eligibility |
Inclusion Criteria:
- In order to be eligible to participate in this study, participants must meet all of
the following criteria:
1. Age = 18 years old at the date of screening
2. Have both clinical and radiographic findings consistent with osteoarthritis of
the knee:
1. Participant has clinical findings including (but not limited to) tenderness
to palpation, swelling/effusion, stiffness, chronic limited range of motion.
2. Participant has a diagnosis of knee OA defined as Grade 2 to 3 by (K/L)
weight bearing X-ray and physician review within the past 3 months.
3. The index knee must present with symptomatic knee pain using WOMAC-A Visual
Analog Scale (VAS) of 40mm or greater despite conservative therapies for 3 months
prior to enrollment:
a. Failure of conservative therapies include the following: Participants must
have failed a minimum of at least 3 months, including (1) physical therapy, and
(2) oral OTC pain medications such as an NSAID (Aleve® or Advil®) or
Acetaminophen (Tylenol®), or a prescription NSAID, for a period of 90 days at the
Maximum Tolerable Dose according to the respective manufacturer's instructions on
dose and duration, or their physician's over-riding guidance. Patients who are
unable to tolerate this dosing regimen for 90 days, or those in whom NSAIDS or
Acetaminophen are contraindicated, shall be deemed to have satisfied this
inclusion criteria.
4. Willing to give written Informed Consent to voluntarily participate in the study
and sign the Health Insurance Portability and Accountability Act (HIPAA)
Authorization prior to study participation
5. Ability to return for multiple follow-up visits
6. Ability read and understand English language
7. Females of child-bearing potential must have a negative urine pregnancy test
performed within 7 days of study enrollment or be postmenopausal (for at least 2
years) or surgically sterilized (bilateral tubal ligation, bilateral
oophorectomy, or hysterectomy)
Exclusion Criteria:
- Participants who meet any of the following criteria will be excluded from
participating in this study. Study eligibility of participants reporting isolated use
of prohibited medications during the restricted periods defined by this protocol, will
be evaluated on a case-by-case basis by the medical monitor.
1. Diagnosis of knee OA defined as K/L grade 1 or 4.
2. BMI greater than 35 kg/m2.
3. Diagnosis of rheumatoid arthritis, psoriatic arthritis, or any other disorder
which attributes to the primary source of their knee pain, including but not
limited to: osteonecrosis, radiculopathy, bursitis, tendinitis, tumor, cancer.
4. Presence of any clinically observed active infection including in the index knee
joint, infection at the site of adipose tissue harvest, and/or any active
systemic or local infection.
5. Undergone injection in target knee within 6 months prior to screening visit,
including but not limited to corticosteroids, hyaluronic acid (HA), bone marrow
concentrate (BMAC) platelet rich plasma (PRP), human cellular exosomes, amniotic
fluid or any human birth tissue.
6. Undergone surgical procedures of either knee within 6 months prior to the
screening visit.
7. Bilateral knee pathology can only be treated in one knee for the study. The
contralateral knee must have a WOMAC-A Visual Analog Scale (VAS) pain score of no
more than 20mm for the past 3 months prior to enrollmentat the time of screening
(48-hr recall).
8. Index knee greater than 10 degrees varus/valgus deformities (anatomic
tibiofemoral angle).
9. Knee pain associated with osteochondritis dissecans, ligament damage or displaced
meniscus tear.
10. Current or historical autoimmune disease that requires immunosuppressive
medication.
11. Any disorder affecting musculoskeletal pain and/or function, including
symptomatic OA of the back, hips, or ankle that would interfere with the
evaluation of the treated knee.
12. Planned or expected surgery within the next 12 months.
13. Allergy to lidocaine, epinephrine, or valium.
14. Diagnosis of HIV or viral hepatitis.
15. Use of oral systemic corticosteroids within the last 90 days and for the duration
of the study.
16. History of any chemotherapy or radiation therapy of the targeted/treatment leg or
adipose harvest site.
17. Active worker's compensation case.
18. Known hypersensitivity/contraindication to corticosteroid injections.
19. Diagnosis of coagulation disorders (e.g., Von Willebrand's disease) and/or
currently on anti-coagulant therapy.
20. Occurrence of knee trauma to the index knee within six months prior to screening.
21. Unwilling to stop usage of over-the-counter pain medication (e.g., Acetaminophen
or NSAID), "Rescue Analgesics", for 7 days prior to any follow-up visit, with the
exception of one "baby aspirin" per day for cardiovascular therapy or
prophylaxis.
22. Unwilling to stop taking prescription pain or prescription anti-inflammatory
medication for the duration of the study, with the exception of Tramadol during
the immediate post-procedure period noted below.
23. Unwilling to abstain from NSAIDS for 7 days pre-injection and 2 weeks
post-injection. Tramadol is allowed during the 72 hours immediately
post-injection, with diary documentation of usage.
24. Currently taking prescription pain medication for a condition other than the
index knee.
25. Currently in prison.
26. Untreated symptomatic injury of the index knee (e.g., acute traumatic injury,
anterior cruciate ligament injury, clinically symptomatic meniscus injury
characterized by mechanical issue such as locking or catching).
27. Impossibility to harvest enough adipose tissue.
28. Any medical issue that the clinician feels would be a contraindication to the
study treatment including, but not limited to:
1. Uncontrolled diabetes defined as HbA1c >7%,
2. History of uncontrolled hypertension defined by average systolic BP >140
mmHg or diastolic BP > 90 mmHg on = 3 blood pressure medications,
3. History of cardiovascular disease,
4. History of cerebrovascular disease,
5. Uncontrolled asthma, defined as symptomatic (i.e., shortness of breath
and/or wheezing) despite therapy,
6. History of solid organ or hematologic transplantation,
7. Diagnosis of non-basal cell malignancy within preceding 5 years,
8. Change in prescription medication within 1 month prior to enrollment,
9. Clinically significant abnormalities in vital signs at the time of screening
defined by
- Systolic BP >140 or <90 mmHg or diastolic BP >90 or <60 mmHg
- Pulse <55 or >100 bpm
- Respiratory Rate <9 or >20
- Temperature >99 °F
29. History of septic arthritis or sepsis/bacteremia in the affected knee within 6
months prior to screening, or infection requiring antibiotic treatment within the
preceding 3 months.
30. Women who are breastfeeding.
31. Unwilling to use contraception for 3 months post procedure unless postmenopausal
(for at least 2 years) or surgically sterilized (bilateral tubal ligation,
bilateral oophorectomy, or hysterectomy).
|
