Clinical Trials Logo
  1. Home
  2. Knee Osteoarthritis
  3. NCT05398874
  4. Details
NCT05398874 Clinical Trial

Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:
Clinical Efficacy of Ginkgo Biloba Extract in the Treatment of Knee Osteoarthritis

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05398874
Other study ID # MEC-13
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date November 1, 2021
Est. completion date August 1, 2022

Study information
Verified date September 2022
Source Kufa University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

To assess the efficacy and safety of the Ginkgo biloba extract in patients with Knee OA.

Recruitment information / eligibility
Status Completed
Enrollment 60
Est. completion date August 1, 2022
Est. primary completion date June 1, 2022
Accepts healthy volunteers No
Gender All
Age group 40 Years to 75 Years
Eligibility Inclusion Criteria: - patients 40-75 years old with knee OA. - Grade II and Grade III according to the Kellgrenn-Lawrence (KL) grading system of radiographic OA. Exclusion Criteria: - Pregnancy, breastfeeding - Liver or renal problems - Patient taking any drug that might interact with Ginkgo extract (eg. warfarin, etc.) - patient with cardiovascular or cerebral vascular disorders, uncontrolled diabetes, allergic to ginkgo, recent surgery or hospital admission, >75 years old. - Allergic or contraindicated to using NSAIDs

Study Design

Related Conditions & MeSH terms

Intervention

Combination Product:
• Ginkgo biloba extract + standard treatment( paracetamol+Diclofenac100mg SR)
120 mg leaf extract , twice daily in addition to Diclofenac 100 mg Once daily + paracetamol 1g Twice daily
• placebo in addition to the standard treatment
placebo in addition to the standard treatment

Locations
Country Name City State
Iraq Private Clinic Najaf N/A (Outside Of US)

Sponsors (1)
Lead Sponsor Collaborator
Kufa University

Country where clinical trial is conducted

Iraq, 

Outcome
Type Measure Description Time frame Safety issue
Primary KOOS score 42 item questionnaire to assess pain, other symptoms, activities of daily living (ADL), sport and recreation function (Sport/Rec) and knee-related quality of life (QOL). Changes occured : baseline , 2 weeks , 4 weeks ,and 8 weeks
Secondary IL-6 Serum level of interleukin 6 Changes occured: baseline , 4 weeks,and 8 weeks
Secondary TNF-alpha Serum level of tumour necrosis factor - alpha Changes occured: baseline , 4 weeks,and 8 weeks
Secondary urinary CTX-II C-terminal telopeptide of type II collagen from urine samples Changes occured :baseline , 4 weeks,and 8 weeks
See also
  Status Clinical Trial Phase
Recruiting NCT04651673 - Prescribed Knee Brace Treatments for Osteoarthritis of the Knee (Knee OA)
Completed NCT05677399 - Knee Osteoarthritis Treatment With Peloidotherapy and Aquatic Exercise. N/A
Active, not recruiting NCT04043819 - Evaluation of Safety and Exploratory Efficacy of an Autologous Adipose-derived Cell Therapy Product for Treatment of Single Knee Osteoarthritis Phase 1
Recruiting NCT06000410 - A Study to Evaluate the Efficacy of Amniotic Suspension Allograft in Patients With Osteoarthritis of the Knee Phase 3
Completed NCT05014542 - Needling Techniques for Knee Osteoarthritis N/A
Recruiting NCT05892133 - Prehabilitation Effect on Function and Patient Satisfaction Following Total Knee Arthroplasty N/A
Recruiting NCT05528965 - Parallel Versus Perpendicular Technique for Genicular Radiofrequency N/A
Active, not recruiting NCT03472300 - Prevalence of Self-disclosed Knee Trouble and Use of Treatments Among Elderly Individuals
Active, not recruiting NCT02003976 - A Randomized Trial Comparing High Tibial Osteotomy Plus Non-Surgical Treatment and Non-Surgical Treatment Alone N/A
Active, not recruiting NCT04017533 - Stability of Uncemented Medially Stabilized TKA N/A
Completed NCT04779164 - The Relation Between Abdominal Obesity, Type 2 Diabetes Mellitus and Knee Osteoarthritis N/A
Recruiting NCT04006314 - Platelet Rich Plasma and Neural Prolotherapy Injections in Treating Knee Osteoarthritis N/A
Recruiting NCT05423587 - Genicular Artery Embolisation for Knee Osteoarthritis II N/A
Enrolling by invitation NCT04145401 - Post Market Clinical Follow-Up Study- EVOLUTION® Revision CCK
Active, not recruiting NCT03781843 - Effects of Genicular Nerve Block in Knee Osteoarthritis N/A
Recruiting NCT05974501 - Pre vs Post Block in Total Knee Arthroplasty (TKA) Phase 4
Completed NCT05324163 - Evaluate Efficacy and Safety of X0002 in Treatment of Knee Osteoarthritis Phase 3
Completed NCT05529914 - Effects of Myofascial Release and Neuromuscular Training for Pes Anserine Syndrome Associated With Knee Osteoarthritis N/A
Recruiting NCT05693493 - Can Proprioceptive Knee Brace Improve Functional Outcome Following TKA? N/A
Not yet recruiting NCT05510648 - Evaluation of the Effect of High-intensity Laser Therapy in Knee Osteoarthritis N/A