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Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:
Efficacy of Bone-marrow-derived and Placenta-derived Multipotent Mesenchymal Stem / Stromal Cells for Osteoarthritis

Clinical Trial Summary

To define the clinical effects of intra-articular transplantation of bone-marrow-derived (BM-MMSCs) and placenta-derived multipotent mesenchymal stem / stromal cells (P-MMSCs) for knee osteoarthritis.

Clinical Trial Description

Multipotent mesenchymal stem / stromal cells (MMSCs) of different origin are the novel therapeutic agents that can slow down cartilage degeneration, improve reparation and ultimately prevent joint prosthetics. MSCs are capable to direct differentiation into chondrocytes, produce cytokines and growth factors with immunomodulatory and anti-inflammatory effects, stimulate angiogenesis, as well as induce chemotaxis of endogenous progenitors. Bone marrow-derived and placenta-derived MMSCs can be considered the most promising source for cell therapy of joints disorders according to availability, safety and expected therapeutic efficacy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04453111
Study type Interventional
Source Institute of Cell Therapy
Contact Peter Nemtinov, MD
Phone +380442079207
Email nemtinov@stemcellclinic.com
Status Recruiting
Phase Phase 1/Phase 2
Start date January 2, 2020
Completion date October 2021
View Details
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