Tai Chi for Knee OA Pain Management: a Mechanistic Study

Status Active, not recruiting

Clinical Trial Summary

This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA.

Clinical Trial Description

Knee osteoarthritis (OA) is one of the five leading causes of disability. Previous studies have shown that a mind-body moderate-intensity Tai Chi (TC) exercise (8-24 weeks) reduced pain and improved physical function for knee OA, when compared to a waiting list, attention control, usual physical activity, or physical therapy. However, TC's mechanisms of action regarding improvement of one's clinical condition and its functional outcomes in individuals with knee OA are poorly understood. This study is to determine how 8-week TC intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain white matter connectivity/efficiency, and functional/clinical outcomes in women with knee OA. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04046003
Study type	Interventional
Source	Texas Tech University Health Sciences Center
Contact
Status	Active, not recruiting
Phase	N/A
Start date	September 1, 2019
Completion date	August 31, 2024

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