Collagen-PVP vs Hylan G-F 20 in the Treatment of Knee Osteoarthritis

Status Recruiting

Clinical Trial Summary

Articular cartilage degradation is the main characteristic of osteoarthritis (OA), involving enzymatic and inflammatory mechanisms that change it into a chronic disease. Since articular cartilage shows limited regenerative ability, several intra-articular drugs have been developed in order to decrease inflammation and provide a better clinical outcome to the patient.

Clinical Trial Description

This study aims to compare effectiveness of the treatment with intra-articular administration of collagen-PVP versus hylan GF 20, using the International Knee Documentation Committee (IKDC) score, 6 months after treatment. Hypothesis to test is: If effectiveness of intra-articular collagen-PVP is not lower than hylan GF 20 treatment in knee osteoarthritis subjects, then, statistically significant difference would not exist in IKDC score mean increase among treatment groups, after six months. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04019782
Study type	Interventional
Source	Coordinación de Investigación en Salud, Mexico
Contact	Gabriel J Horta-Baas, MD, Msc
Phone	529998360846
Email	gabho@hotmail.com
Status	Recruiting
Phase	Phase 3
Start date	August 1, 2019
Completion date	August 31, 2021

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