Knee Osteoarthritis Clinical Trial
Official title:
A Prospective, Randomized, Double-blinded, Multi-center, Trial to Evaluate Efficacy and Safety of Combination of Diacerein and Celecoxib Administered Orally in Patients With Knee Osteoarthritis
The purpose of this study is to evaluate the pain relief effect of Co-administration of Diacerein with Celecoxib in patients with knee osteoarthritis compared with single administration of each drug.
A large epidemiological study in Europe reported that over four-thirds of patients with
osteoarthritis received combination therapy with two or more drugs. Approximately 1.5% of
patients with osteoarthritis using three or more drugs are using COX-2(Cyclo-oxygenase-2)
inhibitors and SYSADOA(Symptomatic slow acting drug), And it has been investigated that much
more patients are using the two classes of drugs when the range is extended to other oral
NSAIDs other than COX-2 inhibitors. Therefore, considering the characteristics of patients
with osteoarthritis, such as basal disease and treatment effects on each type of drug, it is
important to find the optimal combination of drugs for each patient characteristics.
There is a previous study using osteoarthritis rat model as a biological basis of diacerein
and celecoxib administration. Previous studies have shown that the combined use of Diacerein
and Celecoxib improves osteoarthritis.
The purpose of this study is to evaluate the pain relief effect of Co-administration of
Diacerein with Celecoxib in patients with knee osteoarthritis compared with single
administration of each drug.
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