The Maximum Tolerated Dose of Mesenchymal Stem Cells From Umbilical Cord

Status Not yet recruiting

Clinical Trial Summary

The aim of this study was to evaluate the maximum tolerated dose of Mesenchymal Stem Cells (MSCs) from umbilical cord in the treatment of human knee OA

Clinical Trial Description

This is a single-centre, quadruple blined, randomized controlled trail with a total of 9 knee osteoarthrits patients as participants, who will be randomly assigned into high dose group, moderate dose group or low dose group. The participants in the high dose group will receive the treatment of high dose MSCs (1×10^8cells/3mL) anticular injection.The dose of the MSCs in medium dose group is 5×10^7cells/3mL, and the dose in the low dose group is 1×10^7cells/3mL. Unexplained local and systemic symptoms will be assessed to determine the the maximum tolerated dose of mesenchymal stem cells in anticular injection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03357770
Study type	Interventional
Source	Peking University People's Hospital
Contact	Ziyi Yang
Phone	+86 18810335110
Email	bjmuyangziyi@163.com
Status	Not yet recruiting
Phase	N/A
Start date	January 1, 2018
Completion date	June 1, 2021

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