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The Combination Effect of Platelet-rich Plasma and Hyaluronic Acid for Knee Osteoarthritis

Knee Osteoarthritis Clinical Trial

Official title:
The Combination Long-term Effect of Platelet-rich Plasma and Hyaluronic Acid in Patients With Knee Osteoarthritis: a Prospective Randomized Double-blind Controlled Trial

Clinical Trial Summary

Although platelet rich plasma (PRP) and Hyaluronic acid (HA) are beneficial for osteoarthritis of knee (OA knee), the combined effect of PRP with HA was not clear so far. Hence, investigator assess a prospective randomized double-blind controlled trial.

Clinical Trial Description

Patients with single or bilateral OA knee will be enrolled and randomized into intervention and control group. One dose of PRP is applied into both groups. One week later, one dose of HA is injected in intervention group and one dose of normal saline is injected in control group. Outcome measurements included visual analog scale (VAS)、Lequesne's severity index、Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)、balance test (Biodex) and analysis of synovial fluid at different follow-up frame (1st month, 3rd month, 6th month and 1 year after treatment). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03290365
Study type Interventional
Source Tri-Service General Hospital
Contact
Status Completed
Phase N/A
Start date January 10, 2018
Completion date July 1, 2021
View Details
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