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Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys — HMPO2  

Kidney Transplant; Complications Clinical Trial

Official title:
A Prospective Feasibility Trail to Compare the Efficacy of Intermittent Surface Oxygenation With Continuous Surface Oxygenation During Hypothermic Machine Perfusion of Kidneys Donated After Circulatory Death

Clinical Trial Summary

The aim of the study is to evaluate the feasibility of this bubble and surface oxygenation and to determine the optimal timing of surface oxygenation (continuous versus intermittent) as alternative for membrane-oxygenated kidneys, originating from DCD donors, during HMP on early graft function in clinical practice.

Clinical Trial Description

Kidneys originating from deceased donors after circulatory death (DCD), category 3 and 5 (controlled) will be preserved from procurement until transplantation on hypothermic machine perfusion conditions and prospectively randomized into 2 study groups: 1) intermittent surface oxygenation during HMP (surface oxygenation interrupted during organ transport (2-4h)(I-HMPO2 group), and 2) continuous surface oxygenation during HMP (surface oxygenation during the whole machine preservation period included organ transport)(C-HMPO2 group). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05430620
Study type Interventional
Source Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Contact Tom Darius, Phd
Phone 003227642218
Email tom.darius@saintluc.uclouvain.be
Status Recruiting
Phase Phase 3
Start date March 20, 2022
Completion date January 1, 2026
View Details
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