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Clinical Trial Summary

The purpose of this study is to compare two medications that reverse muscle paralysis at the end of kidney transplant surgery with the goal of reducing residual muscle weakness and insufficient respiratory function after surgery.


Clinical Trial Description

This is a prospective randomized double-blind single center study on patients with severe kidney failure undergoing kidney transplantation surgery. Patients will have their muscles paralyzed during general anesthesia for surgery. At the end of surgery, muscle paralysis will be reversed with either neostigmine (control group) or sugammadex (intervention group). Residual muscle weakness and respiratory function will be monitored after surgery with a quantitative train-of-four (qTOF) monitor and a noninvasive continuous ventilation monitor. The investigators hypothesize that patients receiving sugammadex will have less residual muscle weakness and better respiratory function than patients receiving neostigmine. Respiratory and kidney function parameters and any adverse events will be collected during the hospital stay. Patients will contacted for a study follow up around 2 weeks after their surgery. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT03923556
Study type Interventional
Source University of Colorado, Denver
Contact Ana Fernandez-Bustamante, M.D., Ph.D.
Phone 303-724-2935
Email ana.fernandez-bustamante@cuanschutz.edu
Status Recruiting
Phase Phase 4
Start date February 2, 2021
Completion date December 30, 2023

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