Kidney Transplant; Complications Clinical Trial
Official title:
Comparison of Two Different Preload Targets of Stroke Volume Variation During Kidney Transplantation: A Randomized Controlled Trial
Verified date | October 2021 |
Source | Seoul National University Hospital |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators sought to compare the effect of two preload targets of stroke volume variation of ≤6% and ≤12% on the postoperative renal function in patients undergoing living donor kidney transplantation. Goal-directed fluid therapy will be performed in both groups to maintain adequate stroke volume, stroke volume variation, mean arterial pressure (or systemic vascular resistance) during kidney transplantation. Only the preload target for giving crystalloid during surgery will be different between groups.
Status | Completed |
Enrollment | 60 |
Est. completion date | November 25, 2020 |
Est. primary completion date | November 25, 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - Adults patients who are undergoing living donor kidney transplantation with continuous radial artery pressure monitoring Exclusion Criteria: - Patients who have cardiac arrhythmia of atrial fibrillation, multiple ventricular premature complex - Cardiac systolic dysfunction with left ventricle ejection fraction <50% - Continuous arterial pressure monitoring at the site other than radial artery. - Patients who are considered to be intolerant to rapid fluid administration |
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Seoul National University Hospital | Seoul |
Lead Sponsor | Collaborator |
---|---|
Seoul National University Hospital |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | serum neutrophil-gelatinase-associated lipocalin (NGAL) | urine biomarker of renal injury | at the end of surgery | |
Secondary | serum neutrophil-gelatinase-associated lipocalin (NGAL) | urine biomarker of renal injury | at the anesthesia induction procedure | |
Secondary | Delayed graft function determined by the incidence of hemodialysis | Delayed graft function determined by the incidence of hemodialysis | during the first postoperative week | |
Secondary | Delayed graft function determined by urine output (less than 1200 ml) | Delayed graft function determined by urine output (less than 1200 ml) | during the first postoperative day | |
Secondary | Delayed graft function determined by serum creatinine | Delayed graft function determined by serum creatinine (No decrease in creatinine of more than 10% of preoperative value) | during the 48 hours after surgery | |
Secondary | Delayed graft function determined by serum creatinine (more than 2.5 mg/dL) | Delayed graft function determined by serum creatinine (more than 2.5 mg/dL) | during the 10 days after surgery | |
Secondary | Delayed graft function determined by glomerular filtration rate | Delayed graft function determined by glomerular filtration rate (less than 10 ml/min/m2) | during the 24 hours after surgery | |
Secondary | Delayed graft function determined by serum creatinine (do not decrease less than preoperative value) | Delayed graft function determined by serum creatinine (do not decrease less than preoperative value) | during the first postoperative week | |
Secondary | Immediate graft function | serum creatinine decrease less than 70% of preoperative value | after eight days after surgery | |
Secondary | slow graft function | serum creatinine decrease greater than 70% of preoperative value | after eight days after surgery | |
Secondary | serum creatinine value | serum creatinine value | first postoperative day | |
Secondary | serum creatinine value | serum creatinine value | third postoperative day | |
Secondary | serum creatinine value | serum creatinine value | seventh postoperative day | |
Secondary | Incidence of pneumonia | Incidence of pneumonia | during the first postoperative week | |
Secondary | Incidence of wound infection | Incidence of wound infection | during the first postoperative week | |
Secondary | Incidence of postoperative bleeding | Incidence of postoperative bleeding | during the first postoperative week | |
Secondary | hospital length of stay | hospital length of stay | the first postoperative month |
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