Treatment Optimization & Nephrolithiasis Recurrence Prevention With

Status Recruiting

Clinical Trial Summary

Nearly 10% of the Belgian population suffer from kidney stone disease. Recent reviews reported that kidney stones represent an underestimated risk factor for further kidney function deterioration. Preventive measures are recommended in lithiases patients to prevent the formation of new stones. The individual effects of different medicated prosthetic interventions have been documented in clinical trials. However, there is little data on the effectiveness of combining these different preventive measures in routine clinical practice (real-world context). Patients with kidney stone disease require a complete metabolic assessment. The three main factors contributing to the stone's formation are the patient's metabolism, diet and lifestyle. Metabolic work-up is recommended by the American Urology Association to identify and correct the factors responsible for urinary stone formation such as hypercalciuria, hyperoxaluria, hyperuricuria, hypocitraturia or abnormalities of urinary pH. The metabolic work-up includes at minimum the 24h urine test, a blood test and spot urine test. Dietary habits and lifestyle are assessed by means of a questionnaire. The CHU Brugmann Hospital has a specialized multidisciplinary clinic for renal lithiases and mineral metabolism. Preventive personalized and interdisciplinary care in CHU Brugmann consists of a full metabolic work-up allowing the identification of lithogenic risk factors by nephrologists, dietary assessment by specialized dieticians and specific treatment protocol associated with regular follow-up. The aim of this study is to evaluate, in the context of a retrospective single-center cohort study, the effect of preventive personalized and interdisciplinary care on the evolution of all urinary lithogenic risk factors and the recurrence of kidney stones (rate of renal colics, emergency room admissions, and urological interventions).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06367894
Study type	Observational
Source	Brugmann University Hospital
Contact	Sirika Chhem
Phone	024772641
Email	Sirika.Chhem@ulb.be
Status	Recruiting
Phase
Start date	December 12, 2023
Completion date	December 31, 2024

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT04495699` - Asymptomatic Renal Calculi in Recurrent Urinary Tract Infections
Recruiting	`NCT04559321` - Holmium Vs Trilogy Kidney Stones GUY's 1-2	Phase 3
Completed	`NCT04332861` - Evaluation of Infection in Obstructing Urolithiasis
Withdrawn	`NCT06138327` - A Study of BMN 255 in Participants With Non-Alcoholic Fatty Liver Disease And Hyperoxaluria	Phase 1
Not yet recruiting	`NCT05022537` - Clinical Outcomes of Percutaneous Nephrolithotomy Following Retrograde Percutaneous Nephrostomy Access Using Novel Device in Comparison to Antegrade Access	N/A
Completed	`NCT03872843` - Opioid Free Management After Ureteroscopy	Phase 4
Recruiting	`NCT06412822` - Neutrophil Extracellular Traps (NET's) in Prevalent Kidney Stone
Active, not recruiting	`NCT06437379` - Infection Control Measures for Patients Undergoing Percutaneous Nephrolithotomy	N/A
Recruiting	`NCT04997668` - Clinical Outcomes and Healthcare Economics of SOLTIVE Compared to Ho:YAG Laser in Urolithiasis	N/A
Active, not recruiting	`NCT04333745` - Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers	N/A
Recruiting	`NCT05701098` - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)	N/A
Recruiting	`NCT04389853` - Mini-PNCL vs fURS in Management of Nephrolithiasis	N/A
Recruiting	`NCT05334979` - Oxalate and Citrate	N/A
Recruiting	`NCT05591716` - Evaluation of the Efficacy and Safety of Unimodal Bilateral Flexible Ureteroscopy.	N/A
Recruiting	`NCT06209931` - RIRS With Tip Flexible Pressure-controlling Ureteral Access Sheath Versus Mini PCNLfor Kidney Stones
Withdrawn	`NCT04545528` - The Impact of Nutritional Service in the Stone Clinic on the Patient Urine Collection Results
Completed	`NCT05714423` - Outcomes in Lower Pole Kidney Stone Management Using Mini-PCNL Compared With Retrograde Intra Renal Surgery	N/A
Recruiting	`NCT03281928` - Effect of Dietary Sodium and Potassium Citrate on Renal Mineral Handling	N/A
Recruiting	`NCT04835922` - Comparison of Efficacy of Intercostal Nerve Block vs Peritract Infiltration With 0.25% Bupivacaine in PCNL	N/A
Recruiting	`NCT03257306` - Magnetic Ureteral Stent Symptoms - a Comparison to Standard Ureteral Stent as Perceived By the Patient (MAGUSS)	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Treatment Optimization and Nephrolithiasis Recurrence Prevention With Interdisciplinary Care

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms