Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids

Keloid Clinical Trial

Official title: Examining the Therapeutic Potential of Botulinum Toxin Type A in the Treatment of Keloids

Status Active, not recruiting

Clinical Trial Summary

Keloids are a common form of hypertrophic scars that by definition last beyond 6 months and grow beyond the site of initial injury. Keloids are a common complaint from patients in dermatology and cause significant functional impairment due to cosmetic disfigurement, itching and pain. Current treatment modalities include intralesional corticosteroids, chemotherapeutic agents and laser therapy. Initial reports have demonstrated that Botulinum toxin type A may be a viable treatment option for keloids that can reduce keloid size and reduce associated symptoms while having fewer side effects when compared to intralesional corticosteroid injection, which can cause unnatural blood vessel growth or skin thinning. To date, no study has carefully examined the efficacy of Botulinum toxin type A in treating keloids or its mechanistic effects on keloid biology. Our aim in this study is to pursue a rigorous, randomized control trial to assess the potential use Botulinum toxin type A to treat keloids. Efficacy will be objectively be mentioned by change in keloid size after treatment, along with subjective measures of patient satisfaction and symptoms, and finally physician rated scores. Also, samples from three patients will be analyzed in the laboratory setting to determine the underlying molecular mechanism behind the effects of Botulinum toxin type A on keloid biology.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Keloid

• NCT number: NCT05330078
• Study type: Interventional
• Source: University of California, San Diego
• Status: Active, not recruiting
• Phase: Early Phase 1
• Start date: March 11, 2022
• Completion date: January 2032