Clinical Trials Logo

Joint Pain clinical trials

View clinical trials related to Joint Pain.

Filter by:

NCT ID: NCT06444867 Not yet recruiting - Joint Pain Clinical Trials

A Study to Evaluate Efficacy, Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Single Dose of LEO 158968

Start date: June 2024
Phase: Phase 1
Study type: Interventional

The main objective of the study is to evaluate the effect on pain of a single, subcutaneous (SC) dose of LEO 158968 in participants with gout flares.

NCT ID: NCT06444763 Not yet recruiting - Joint Pain Clinical Trials

Effect of Maolactin™ FMR on Exercise Recovery, Inflammation and Muscle Comfort in an Otherwise Healthy Population

Start date: July 31, 2024
Phase: Phase 3
Study type: Interventional

This is a double blind, randomised, placebo-controlled, parallel-group trial to evaluate the effect of Maolactin FMR supplementation on chronic inflammation, mobility and muscle and joint pain in an otherwise healthy population of adults 45-65 years old over 14 weeks with 12 weeks supplementation. This is PART B of the study.

NCT ID: NCT06402448 Recruiting - Joint Pain Clinical Trials

Prevalence of Muscle and Nerve and Joint Pain

Start date: February 1, 2024
Phase:
Study type: Observational

The purpose of the study is to provide adequate information about the percentage of the main tissue that causing pain in most common spinal disorders either it is muscular, nerve or joint in each spinal parts, that will provide the physical therapist with large data that can be helpful in differential diagnosis.

NCT ID: NCT06246383 Not yet recruiting - Joint Pain Clinical Trials

Effectiveness of Cucumber Extract on Joint Pain

Start date: February 2024
Phase: N/A
Study type: Interventional

Joint pain is reported by about 1/3 of U.S. adults, and increases with age reaching 50% prevalence among the elderly [1]. Joint pain is associated with substantial activity limitation, work disability, sleep disturbance, negative mood (e.g., depression, anxiety, stress), and reduced quality of life (2, 3). Conventional treatment of joint pain with non-steroidal anti-inflammatory drugs (NSAIDs) and other analgesics is associated with gastrointestinal and cardiovascular side effects, and other adverse health effects [4]. Use of alternative supplements is reported by about 50% of people with knee osteoarthritis, and well-designed human trials are needed to identify effective analgesic alternatives [5]. The most widely used and studied joint pain supplements include those related to chondroprotection such as glucosamine, chondroitin, collagen hydrolysates, and hyaluronic acid [6-9]. Further research is needed examining the effects of other herbal supplementation on joint pain and overall health. Preliminary research reveals Q-ActinTM supplementation may be an effective intervention to reduce OA-related pain compared with standard treatments. Q-ActinTM is a cucumber extract with the anti-inflammatory iminosugar idoBR1 standardised to over 1%. Study Purpose To conduct a 8 week randomized double-blind placebo-controlled trial to examine the effectiveness of daily use of Q-ActinTM supplementation compared to placebo on joint pain, stiffness, function, mood, sleep, daytime activity, and health-related quality of life in adults with a history (>3 months) of mild to moderate joint pain.

NCT ID: NCT06123286 Not yet recruiting - Breast Cancer Clinical Trials

Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms

Start date: July 2024
Phase: Early Phase 1
Study type: Interventional

Both Tart Cherry and Omega 3 FAs have better side effect profiles compared to other commonly used medications for AIMSS, such as nonsteroidal anti-inflammatories, steroids, and serotonin norepinephrine reuptake inhibitors. Additionally, in our clinics the investigators often find that patients tend to be more receptive to taking a supplement as opposed to an additional medication. Further, both Tart Cherry concentrate and fish oil have beneficial properties for helping with joint stiffness in general, in addition to other health issues like insomnia. There is some evidence in mouse models that when given together, these supplements may have an even greater anti-inflammatory effect than when taken separately. Although to our knowledge, no human studies have tested this hypothesis. This study has been designed to test the hypothesis that Tart Cherry and fish oil when given in combination over a 12-week period could produce beneficial changes in arthritis symptoms when compared to a control group in an obese breast cancer population experience AIMSS and on an AI. Secondary outcomes to be assessed include pain, functional performance, quality of life and cognition.

NCT ID: NCT06074744 Recruiting - Joint Diseases Clinical Trials

Subsartorial Nerve Block and Femoral Nerve Block in Total Knee Arthroplasty

Start date: November 30, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to compare two different types of nerve blocks in patients undergoing surgery for primary Total Knee Arthroplasty. The main question aim to answer is: - is there a benefit in functional muscle power output of the leg? Participants will be randomized into either the intervention group or the control group and: - receive Subsartorial Saphenous Nerve Block (SSNB) + IPACK in intervention group (group 1) - receive Femoral Nerve Block (FNB) + IPACK in control group (group 2) Researchers will compare the 2 groups to see if there are differences in : - functional muscle power output of the leg? - muscle function, mobility, clinical and radiological results, ROM, pain control (NRS), opioid consumption, length of hospital stay, patient satisfaction, mobility, reduction of costs?

NCT ID: NCT05908552 Not yet recruiting - Chronic Pain Clinical Trials

Topical Cannabis for Chronic Musculoskeletal Pain

Start date: July 1, 2023
Phase:
Study type: Observational

Our proposal objective is to evaluate if state-regulated topical CBD-based products relieve chronic musculoskeletal pain and/or absorb into the bloodstream.

NCT ID: NCT05871112 Completed - Knee Osteoarthritis Clinical Trials

Femoral Rotation and Patellar Positioning After TKA

Start date: January 4, 2021
Phase:
Study type: Observational

Analysis of patellar positioning in the trochlear groove after TKA with and without the use of dynamic tensioner.

NCT ID: NCT05825222 Completed - Joint Pain Clinical Trials

A Study to Evaluate the Efficacy of E-PR-01 on Musculoskeletal Health in Physically Active Individuals

Start date: April 28, 2023
Phase: N/A
Study type: Interventional

The present study is a randomized, placebo-controlled, parallel-group, double-blind (double-dummy) clinical study. Not more than 210 individuals will be screened, and considering a screening failure rate of 18%, approximately 168 participants will be randomized in a ratio of 1:1:1 to receive E-PR-01 (LD: 200 mg/day), E-PR-01 (HD: 400 mg/day), or placebo (400 mg/day). After accounting for a dropout/withdrawal rate of 15%, each group will have at least 48 completed participants with equal numbers of participants having knee and lumbo-sacral as index joint. The intervention duration for all the study participants will be approximately 90 days.

NCT ID: NCT05658575 Recruiting - Arthritis Clinical Trials

Study of Dapansutrile Tablets in Subjects With an Acute Gout Flare

Start date: January 6, 2023
Phase: Phase 2/Phase 3
Study type: Interventional

The purpose of this trial is to investigate the efficacy and safety of dapansutrile (OLT1177®) tablets in subjects with an acute gout flare.