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Clinical Trial Summary

The goal of this clinical trial is to study the effects of aerobic exercise during the early rehabilitation after ischemic stroke. The main questions it aims to answer are: - How is the recovery of motor function affected by regularly walking during the first 90 days after an ischemic stroke? - Does regularly walking during the first 90 days after ischemic stroke affect cognition, physical comfort and the immune system? Participants will exert a heart rate controlled walking programme of walking 3-5 times 30-45 minutes per week. Researchers will compare the recovery of the walking group to a control group without any demands regarding physical exercise.

Clinical Trial Description

From animal experiments we know that wheel running has a positive impact on functional recovery after experimental stroke. We aim to translate this observations from our animal experiments into the clinic. Therefore, patients will be included shortly after ischemic stroke and start an aerobic exercise programme during the first 14 days after the event. At baseline visit the participants receive a neuropsychological testing with the focus on cognition, fatigue and depressive symptoms. Furthermore, we perform blood sampling for analysis of the activation state of the peripheral immune system. The patients receive a bicycle ergometry with measurement of the 4 mmol lactate threshold to define the optimal heart rate range for their walking exercise. Moreover, in addition to assessment of the motor function by the fugl-meyer test we perform an innovative testing by a "speedzone". Patients have to react in response to a visual stimulus and the reaction latency is acquired. For correlation with training-induced structural changes participants receive cerebral magnetic resonance imaging to assess the density of axonal fibre tracts (assessed by MRI-DTI). During the following 90 days participants in the intervention group are instructed to walk 3-5 times for 30-45 minutes per week and control the exercise intensity by optical heart rate measurement via smartwatch. The daily step amount will be controlled by the intervention and the control group. Participants will measure their resting heart rate in the morning before getting up to prevent overexercising. The assessments of the baseline visit will be repeated after 90 days. After 45 days participants will receive an additional blood sampling and characterising of the activation state of the immune system. ;

Study Design

Related Conditions & MeSH terms

NCT number NCT05690165
Study type Interventional
Source University Hospital Muenster
Contact Antje Schmidt-Pogoda, MD
Phone +49 (0) 251-8341155
Status Recruiting
Phase N/A
Start date October 26, 2022
Completion date October 1, 2026

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