Direct Mechanical Thrombectomy Versus Bridging Therapy

Ischemic Stroke Clinical Trial

Official title: A Comparative Study of The Efficacy and Safety of Direct Mechanical Thrombectomy Versus Bridging Therapy in Large Vessel Occlusion: An Egyptian Single-Center Experience

Status Completed

Clinical Trial Summary

This study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at Alexandria University in Egypt.

Clinical Trial Description

This study compares the efficacy and safety of direct mechanical thrombectomy versus bridging therapy in patients with anterior circulation large vessel occlusion in a cohort of patients treated at the stroke unit of a single centre at Alexandria University in Egypt. In the first arm, 17 patients were recruited and underwent direct mechanical thrombectomy without receiving recombinant tissue plasminogen activator. In the bridging therapy arm, 34 patients received first tissue plasminogen activator then underwent direct mechanical thrombectomy. The efficacy was evaluated by the NIHSS improvement 24 hours following stroke onset and the modified Rankin scale 3 months following stroke. Safety was assessed by the procedural complications rate especially the hemorhagic transformation. ;

Related Conditions & MeSH terms

• Atherosclerosis
• Ischemic Stroke
• Large-Artery Atherosclerosis (Embolus/Thrombosis)
• Thrombectomy
• Thrombosis

• NCT number: NCT05155540
• Study type: Interventional
• Source: Alexandria University
• Status: Completed
• Phase: Phase 4
• Start date: July 1, 2019
• Completion date: September 1, 2020