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Reducing Intracranial atheroSclErosis With Repatha — RISER  

Ischemic Stroke Clinical Trial

Official title:
Reducing Intracranial atheroSclErosis With Repatha

Clinical Trial Summary

The purpose of this study will be to understand the underlying mechanism by which PCSK9 inhibition reduces the rate of ischemic stroke seen in the pivotal studies that led to its FDA approval for ASCVD such as ischemic stroke. Those trials (FOURIER and ODYSSEY) enrolled almost 50,000 patients and showed that PCSK9 inhibition therapy is safe and effective. The investigators hypothesize that PCSK9 inhibition lowers the rate of stroke by reducing atherosclerotic plaque, which would be particularly beneficial for patients with intracranial atherosclerosis, who have the highest rate of recurrent stroke of any stroke mechanism.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04573010
Study type Interventional
Source University of Utah
Contact
Status Withdrawn
Phase Phase 4
Start date December 1, 2020
Completion date December 1, 2024
View Details
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