Ischemic Stroke Clinical Trial
Official title:
Effect of External Counter Pulsation on IschemicStroke (ECP-STROKE)
Stroke is a prevalent atherosclerosis vascular disease with high mortality, external counter pulsation (ECP) is an approved noninvasive therapy for angina, congestive heart failure, myocardial infarction, and cardiogenic shock that augments blood flow to cardiac and systemic circuits, which improves the flow volume in the carotid. Though ECP is Ⅱa recommendation for stroke management, no multi-center control clinical study has been reported for prognosis of stroke. The aim of this study is to evaluate the effect of ECP on stoke. To address this assumption, investigators enroll subjects with ischemic stroke and randomized into control or ECP group, the ECP intervention will be carried out with a standard protocol which involves 35 one-hour sessions (5 days a week) for continuous 7 weeks. The primary endpoint is mRS score in 3 months, secondary endpoints include NIHSS, BI and MMSE score, recurrence of stroke in 3 months, glycolipid metabolism, transcranial doppler (TCD) flow velocities and endothelial function.
Status | Not yet recruiting |
Enrollment | 380 |
Est. completion date | June 30, 2019 |
Est. primary completion date | May 31, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of ischemic stroke - Exclusion cerebral hemorrhage after CT scan - NIH Stroke Scale (NIHSS)=4 - Modified Rankin Scale (mRS) 0-1 - Signed informed consent Exclusion Criteria: - Obvious aortic insufficiency; - Aortic aneurysm or aortic dissection; - Coronary fistula or severe coronary aneurysm; - Not controlled bleeding disease with INR>2.0 ; - Symptomatic Congestive heart failure - Valvular heart disease, congenital heart diseases, cardiomyopathies - Cerebral hemorrhage within six months; - Uncontrolled hypertension, defined as SBP=180mmHg or DBP=110mmHg; - Lower limb infection; - Deep venous thrombosis; - Progressive malignancies or diseases with poor prognosis |
Country | Name | City | State |
---|---|---|---|
China | Shenzhen Research Institute, The Chinese University Hong Kong | Shenzhen | Guangdong |
China | The Second Affiliated Hospital of Xi'an Jiaotong University | Xi'an | Shanxi |
China | The Second Affiliated Hospital of Zhengzhou University | Zhengzhou | Henan |
Lead Sponsor | Collaborator |
---|---|
Eighth Affiliated Hospital, Sun Yat-sen University | Second Affiliated Hospital of Xi'an Jiaotong University, Shenzhen Research Institute, The Chinese University Hong Kong, The Second Affiliated Hospital of Zhengzhou University |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | modified Rankin Scale (mRS) score | 3-month mRS score after stroke | Change from Baseline at 3 months | |
Secondary | NIH Stroke Scale (NIHSS) score | 3-month NIHSS score after stroke | Change from Baseline at 3 months | |
Secondary | Barthel Index (BI) | 3-month BI after stroke | Change from Baseline at 3 months | |
Secondary | mini-mental state examination (MMSE) Score | 3-month MMSE after stroke | Change from Baseline at 3 months | |
Secondary | Ischemic area of Cerebral CT image | Ischemic area of 3-month Cerebral CT image | Change from Baseline at 3 months | |
Secondary | Transcranial doppler (TCD) flow velocities | transcranial doppler (TCD) flow velocities | Change from Baseline at 3 months |
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