China Antihypertensive Trial in Acute Ischemic Stroke — CATIS  

Ischemic Stroke Clinical Trial

Official title: Inner Mongolia Stroke Project A Randomized Controlled Trial of Immediate Blood Pressure Reduction on Death and Major Disability in Patients With Acute Ischemic Stroke in China

Status Completed

Clinical Trial Summary

This randomized trial tests the effect of early blood pressure reduction on major disability and death among patients with acute ischemic stroke in china.

Clinical Trial Description

We designed a randomized controlled clinical trial to test:

• The effectiveness of blood pressure reduction among patients with acute ischemic stroke (within 48 hours of onset) on the primary outcome, a combination of death within 14 days after randomization and dependency (modified Rankin scale ≥3) at 14 day or at the time of discharge, if that occurred before 14 days.

• The effectiveness of blood pressure reduction among patients with acute ischemic stroke (within 48-hours of onset) on secondary outcomes:

• Combination of all-cause mortality and dependency over 3, 12, and 24 months of follow-up

• Combined vascular disease events over 3, 12, and 24 months of follow-up (vascular deaths, non-fatal stroke, non-fatal myocardial infarction, coronary revascularization, hospitalized or treated angina, hospitalized or treated congestive heart failure, and hospitalized or treated peripheral arterial disease)

• Recurrent fatal and non-fatal stroke over 3, 12, and 24 months of follow-up

• Neurological functional status measured by NIH Stroke Score and modified Rankin scale at 14 day or discharge after randomization, and over 3, 12, and 24 months of follow-up

• All-cause mortality over 3, 12, and 24 months of follow-up

• Duration of initial hospitalization

• Changes in systolic and diastolic blood pressure within 24 hours and over 7 days, and 14 days ;

Related Conditions & MeSH terms

• Cerebral Infarction
• Ischemia
• Ischemic Stroke
• Stroke

• NCT number: NCT01840072
• Study type: Interventional
• Source: Tulane University
• Status: Completed
• Phase: N/A
• Start date: August 2009
• Completion date: May 2016